The CERHR Expert Panel on Bisphenol A accomplished its analysis in August 2007.

ASH sensory neurons are required in Caenorhabditis elegans for a wide range of avoidance behaviors in response to chemical repellents, high osmotic solutions and nose touch. The ASH neurons are therefore hypothesized to be polymodal nociceptive neurons. To understand the nature of polymodal sensory response and adaptation at the cellular level, we expressed the calcium indicator protein cameleon in ASH and analyzed intracellular Ca(2+) responses following stimulation with chemical repellents, osmotic shock and nose touch. We found that a variety of noxious stimuli evoked strong responses in ASH including quinine, denatonium, detergents, heavy metals, both hyper- and hypo-osmotic shock and nose touch. We observed that repeated chemical stimulation led to a reversible reduction in the magnitude of the sensory response, indicating that adaptation occurs within the ASH sensory neuron. A key component of ASH adaptation is GPC-1, a G-protein gamma-subunit expressed specifically in chemosensory neurons. We hypothesize that G-protein gamma-subunit heterogeneity provides a mechanism for repellent-specific adaptation, which could facilitate discrimination of a variety of repellents by these polymodal sensory neurons.

The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) carried out an analysis of the potential for bisphenol A to trigger opposed results on copy and growth in people. The CERHR Expert Panel on Bisphenol A accomplished its analysis in August 2007. CERHR chosen bisphenol A for analysis as a result of of the: widespread human publicity; public concern for doable well being results from human exposures; high manufacturing quantity; proof of reproductive and developmental toxicity in laboratory animal research Bisphenol A (CAS RN: 80-05-7) is a high manufacturing quantity chemical used primarily in the manufacturing of polycarbonate plastics and epoxy resins.

Polycarbonate plastics are used in some meals and drink containers; the resins are used as lacquers to coat steel merchandise similar to meals cans, bottle tops, and water provide pipes. To a lesser extent bisphenol A is used in the manufacturing of polyester resins, polysulfone resins, polyacrylate resins, and flame retardants. In addition, bisphenol A is used in the processing of polyvinyl chloride plastic and in the recycling of thermal paper. Some polymers used in dental sealants and tooth coatings comprise bisphenol A. The major supply of publicity to bisphenol A for most individuals is assumed to happen via the food regimen.

While air, mud, and water (including pores and skin contact throughout bathing and swimming) are different doable sources of publicity, bisphenol A in meals and drinks accounts for the majority of each day human publicity. The highest estimated each day intakes of bisphenol A in the common inhabitants happen in infants and youngsters. The outcomes of this bisphenol A analysis are printed in an NTP-CERHR Monograph that consists of the (1) NTP Brief and (2) Expert Panel Report on the Reproductive and Developmental Toxicity of Bisphenol A. Additional info associated to the analysis course of, including the peer overview report for the NTP Brief and public feedback acquired on the draft NTP Brief and the closing knowledgeable panel report.

See bisphenol A below “CERHR Chemicals” on the homepage. The NTP reached the following conclusions on the doable results of publicity to bisphenol A on human growth and copy. Note that the doable ranges of concern, from lowest to highest, are negligible concern, minimal concern, some concern, concern, and critical concern. The NTP has some concern for results on the mind, habits, and prostate gland in fetuses, infants, and youngsters at present human exposures to bisphenol A. The NTP has minimal concern for results on the mammary gland and an earlier age for puberty for females in fetuses, infants, and youngsters at present human exposures to bisphenol A.

The NTP has negligible concern that publicity of pregnant girls to bisphenol A will outcome in fetal or neonatal mortality, beginning defects, or lowered beginning weight and development in their offspring. The NTP has negligible concern that publicity to bisphenol A will trigger reproductive results in non-occupationally uncovered adults and minimal concern for staff uncovered to larger ranges in occupational settings.

Myocardial calcium and magnesium in acute ischemic damage.

The impact of ischemic damage on calcium and magnesium distribution in canine myocardial cells was investigated in tissue broken by occlusion of the circumflex department of the left coronary artery for 60 minutes or for 40 minutes adopted by 20 minutes of reperfusion of the broken tissue by arterial blood. No vital change in the focus of these cations was famous in completely ischemic, irreversibly injured myocardial cells, however tissue calcium was markedly elevated in cells killed by an episode of transient ischemia. Tissue water and sodium additionally have been elevated and magnesium was decreased considerably in the transient ischemia mannequin.

Investigation of the localization of the elevated Ca(–) by cellular fractionation and chemical evaluation in addition to by electron miscroscopy and microincineration confirmed that a lot of it was localized in dense our bodies within the mitochondria. Within the intramitochondrial dense our bodies, the calcium appeared to be a precipitate of an as but undefined kind of calcium phosphate. Dormant Bacillus subtilis spores can be induced to germinate by vitamins, in addition to by nonmetabolizable chemical compounds, similar to a 1:1 chelate of Ca(2+) and dipicolinic acid (DPA).

Nutrients bind receptors in the spore, and this binding triggers occasions in the spore core, including DPA excretion and rehydration, and additionally prompts hydrolysis of the surrounding cortex via mechanisms that are largely unknown. As Ca(2+)-DPA doesn’t require receptors to induce spore germination, we requested if this course of makes use of different proteins, similar to the putative cortex-lytic enzymes SleB and CwlJ, that are concerned in nutrient-induced germination.

ASH sensory neurons are required in Caenorhabditis elegans for a wide range of avoidance behaviors in response to chemical repellents, high osmotic solutions and nose touch. The ASH neurons are therefore hypothesized to be polymodal nociceptive neurons. To understand the nature of polymodal sensory response and adaptation at the cellular level, we expressed the calcium indicator protein cameleon in ASH and analyzed intracellular Ca(2+) responses following stimulation with chemical repellents, osmotic shock and nose touch. We found that a variety of noxious stimuli evoked strong responses in ASH including quinine, denatonium, detergents, heavy metals, both hyper- and hypo-osmotic shock and nose touch. We observed that repeated chemical stimulation led to a reversible reduction in the magnitude of the sensory response, indicating that adaptation occurs within the ASH sensory neuron. A key component of ASH adaptation is GPC-1, a G-protein gamma-subunit expressed specifically in chemosensory neurons. We hypothesize that G-protein gamma-subunit heterogeneity provides a mechanism for repellent-specific adaptation, which could facilitate discrimination of a variety of repellents by these polymodal sensory neurons.

The transient receptor potential channel TRPA1: from gene to pathophysiology.

The Transient Receptor Potential Ankyrin 1 channel (TRPA1), is a member of the massive TRP household of ion channels, and features as a Ca(2+) permeable non-selective cation channel in many alternative cell processes, starting from sensory to homeostatic duties. TRPA1 is extremely conserved throughout the animal kingdom. The solely mammalian TRPA subfamily member, TRPA1, is extensively expressed in neuronal (e.g. sensory dorsal root and trigeminal ganglia neurons)- and in non-neuronal cells (e.g. epithelial cells, hair cells). It reveals 14-19 amino-(N-)terminal ankyrin repeats, an uncommon structural function.

Caspase-2 Fluorometric Assay Kit - 25 assays

GWB-AXR050 25 assays Ask for price

Caspase-9 Fluorometric Assay Kit - 25 assays

GWB-AXR058 25 assays Ask for price

Caspase-5 Fluorometric Assay Kit - 25 assays

GWB-AXR068 25 assays Ask for price

Caspase-4 Fluorometric Assay Kit - 25 assays

GWB-AXR085 25 assays Ask for price

Caspase-10 Fluorometric Assay Kit - 25 assays

GWB-AXR076 25 assays Ask for price

Caspase-6 Fluorometric Assay Kit - 100 assays

GWB-AXR040 100 assays Ask for price

Caspase-6 Fluorometric Assay Kit - 200 assays

GWB-AXR041 200 assays Ask for price

Caspase-6 Fluorometric Assay Kit - 400 assays

GWB-AXR043 400 assays Ask for price

Caspase-3 Fluorometric Assay Kit - 100 assays

GWB-AXR013 100 assays Ask for price

Caspase-3 Fluorometric Assay Kit - 200 assays

GWB-AXR014 200 assays Ask for price

Caspase-3 Fluorometric Assay Kit - 400 assays

GWB-AXR016 400 assays Ask for price

Caspase-1 Fluorometric Assay Kit - 100 assays

GWB-AXR024 100 assays Ask for price

Caspase-1 Fluorometric Assay Kit - 200 assays

GWB-AXR025 200 assays Ask for price

Caspase-1 Fluorometric Assay Kit - 400 assays

GWB-AXR027 400 assays Ask for price

Caspase-8 Fluorometric Assay Kit - 100 assays

GWB-AXR032 100 assays Ask for price

Caspase-8 Fluorometric Assay Kit - 200 assays

GWB-AXR033 200 assays Ask for price

Caspase-8 Fluorometric Assay Kit - 400 assays

GWB-AXR035 400 assays Ask for price

Caspase-2 Fluorometric Assay Kit - 100 assays

GWB-AXR048 100 assays Ask for price

Caspase-2 Fluorometric Assay Kit - 200 assays

GWB-AXR049 200 assays Ask for price

Caspase-2 Fluorometric Assay Kit - 400 assays

GWB-AXR051 400 assays Ask for price

Caspase-9 Fluorometric Assay Kit - 100 assays

GWB-AXR056 100 assays Ask for price

Caspase-9 Fluorometric Assay Kit - 200 assays

GWB-AXR057 200 assays Ask for price

Caspase-9 Fluorometric Assay Kit - 400 assays

GWB-AXR059 400 assays Ask for price

Caspase-5 Fluorometric Assay Kit - 100 assays

GWB-AXR066 100 assays Ask for price

Caspase-5 Fluorometric Assay Kit - 200 assays

GWB-AXR067 200 assays Ask for price

Caspase-5 Fluorometric Assay Kit - 400 assays

GWB-AXR069 400 assays Ask for price

Caspase-4 Fluorometric Assay Kit - 400 assays

GWB-AXR082 400 assays Ask for price

Caspase-4 Fluorometric Assay Kit - 100 assays

GWB-AXR083 100 assays Ask for price

Caspase-4 Fluorometric Assay Kit - 100 assays

GWB-AXR084 100 assays Ask for price

Caspase-10 Fluorometric Assay Kit - 100 assays

GWB-AXR074 100 assays Ask for price

Caspase-10 Fluorometric Assay Kit - 200 assays

GWB-AXR075 200 assays Ask for price

Caspase-10 Fluorometric Assay Kit - 400 assays

GWB-AXR077 400 assays Ask for price

Caspase 6 Fluorometric Assay Kit

55R-1276 25 assays
EUR 467
Description: Assay Kit for detection of Capase 6 activity in the research laboratory

Caspase-6 Fluorometric Assay Kit

K2014-100 100 assays
EUR 322
Description: Detects VEID-dependent caspase activity, highly-sensitive.

Caspase-6 Fluorometric Assay Kit

K2014-200 200 assays
EUR 492
Description: Detects VEID-dependent caspase activity, highly-sensitive.

Caspase-6 Fluorometric Assay Kit

K2014-25 25 assays
EUR 143
Description: Detects VEID-dependent caspase activity, highly-sensitive.

Caspase-6 Fluorometric Assay Kit

K2014-400 400 assays
EUR 789
Description: Detects VEID-dependent caspase activity, highly-sensitive.

Caspase-6 Fluorometric Assay Kit

K114-100 each
EUR 516

Caspase-6 Fluorometric Assay Kit

K114-200 each
EUR 738

Caspase-6 Fluorometric Assay Kit

K114-25 each
EUR 242.4

Caspase-6 Fluorometric Assay Kit

K114-400 each
EUR 1149.6

GWB-AXR013-100T - Caspase-3 Fluorometric Assay Kit - 100 assays

GWB-AXR013-100T 100assays
EUR 629

Caspase-8 IETD-R110 Fluorometric and Colorimetric Assay Kit (25 assays)

30011-1 1KIT
EUR 244.8
Description: Minimum order quantity: 1 unit of 1KIT

Caspase 3 Fluorometric Assay Kit

55R-1269 25 assays
EUR 527
Description: Assay Kit for detection of Capase 3 activity in the research laboratory

Caspase 1 Fluorometric Assay Kit

55R-1272 25 assays
EUR 527
Description: Assay Kit for detection of Capase 1 activity in the research laboratory

Caspase 8 Fluorometric Assay Kit

55R-1274 25 assays
EUR 527
Description: Assay Kit for detection of Capase 8 activity in the research laboratory

Caspase 2 Fluorometric Assay Kit

55R-1278 25 assays
EUR 507
Description: Assay Kit for detection of Capase 2 activity in the research laboratory

Caspase 9 Fluorometric Assay Kit

55R-1280 25 assays
EUR 513
Description: Assay Kit for detection of Capase 9 activity in the research laboratory

Caspase 5 Fluorometric Assay Kit

55R-1282 25 assays
EUR 473
Description: Assay Kit for detection of Capase 5 activity in the research laboratory

Caspase 10 Fluorometric Assay Kit

55R-1284 25 assays
EUR 507
Description: Assay Kit for detection of Capase 10 activity in the research laboratory

Caspase 4 Fluorometric Assay Kit

55R-1286 25 assays
EUR 513
Description: Assay Kit for detection of Capase 4 activity in the research laboratory

Caspase-3 Fluorometric Assay Kit

K2007-100 100 assays
EUR 322
Description: Detects DEVD-dependent caspase activity, highly-sensitive.

Caspase-3 Fluorometric Assay Kit

K2007-200 200 assays
EUR 469
Description: Detects DEVD-dependent caspase activity, highly-sensitive.

Caspase-3 Fluorometric Assay Kit

K2007-25 25 assays
EUR 143
Description: Detects DEVD-dependent caspase activity, highly-sensitive.

Caspase-3 Fluorometric Assay Kit

K2007-400 400 assays
EUR 789
Description: Detects DEVD-dependent caspase activity, highly-sensitive.

Caspase-1 Fluorometric Assay Kit

K2010-100 100 assays
EUR 586
Description: Detects YVAD-dependent caspase activity, highly-sensitive.

Caspase-1 Fluorometric Assay Kit

K2010-200 200 assays
EUR 835.2

Caspase-1 Fluorometric Assay Kit

K2010-25 25 assays
EUR 285.6

Caspase-1 Fluorometric Assay Kit

K2010-400 400 assays
EUR 1303.2

Caspase-8 Fluorometric Assay Kit

K2012-100 100 assays
EUR 322
Description: Detects IETD-dependent caspase activity, highly-sensitive.

Caspase-8 Fluorometric Assay Kit

K2012-200 200 assays
EUR 492
Description: Detects IETD-dependent caspase activity, highly-sensitive.

Caspase-8 Fluorometric Assay Kit

K2012-25 25 assays
EUR 143
Description: Detects IETD-dependent caspase activity, highly-sensitive.

Caspase-8 Fluorometric Assay Kit

K2012-400 400 assays
EUR 789
Description: Detects IETD-dependent caspase activity, highly-sensitive.

Caspase-2 Fluorometric Assay Kit

K2016-100 100 assays
EUR 571
Description: Detects VDVAD-dependent caspase activity, highly-sensitive.

Caspase-2 Fluorometric Assay Kit

K2016-200 200 assays
EUR 835.2

Caspase-2 Fluorometric Assay Kit

K2016-25 25 assays
EUR 285.6

Caspase-2 Fluorometric Assay Kit

K2016-400 400 assays
EUR 1336.8

Caspase-9 Fluorometric Assay Kit

K2018-100 100 assays
EUR 571
Description: Detects LEHD-dependent caspase activity, highly-sensitive.

Caspase-9 Fluorometric Assay Kit

K2018-200 200 assays
EUR 802.8

Caspase-9 Fluorometric Assay Kit

K2018-25 25 assays
EUR 285.6

Caspase-9 Fluorometric Assay Kit

K2018-400 400 assays
EUR 1336.8

Caspase-3 Fluorometric Assay Kit

K105-100 each
EUR 574.8

Caspase-3 Fluorometric Assay Kit

K105-200 each
EUR 744

Caspase-3 Fluorometric Assay Kit

K105-25 each
EUR 248.4

Caspase-3 Fluorometric Assay Kit

K105-400 each
EUR 1174.8

Caspase-9 Fluorometric Assay Kit

K118-100 each
EUR 561.6

Caspase-9 Fluorometric Assay Kit

K118-200 each
EUR 738

Caspase-9 Fluorometric Assay Kit

K118-25 each
EUR 248.4

Caspase-9 Fluorometric Assay Kit

K118-400 each
EUR 1149.6

Caspase-8 Fluorometric Assay Kit

K112-100 each
EUR 574.8

Caspase-8 Fluorometric Assay Kit

K112-200 each
EUR 738

Caspase-8 Fluorometric Assay Kit

K112-25 each
EUR 248.4

Caspase-8 Fluorometric Assay Kit

K112-400 each
EUR 1149.6

Caspase-2 Fluorometric Assay Kit

K116-100 each
EUR 555.6

Caspase-2 Fluorometric Assay Kit

K116-200 each
EUR 738

Caspase-2 Fluorometric Assay Kit

K116-25 each
EUR 242.4

Caspase-2 Fluorometric Assay Kit

K116-400 each
EUR 1149.6

Caspase-1 Fluorometric Assay Kit

K110-100 each
EUR 574.8

Caspase-1 Fluorometric Assay Kit

K110-200 each
EUR 744

Caspase-1 Fluorometric Assay Kit

K110-25 each
EUR 248.4

Caspase-1 Fluorometric Assay Kit

K110-400 each
EUR 1149.6

Caspase-5 Fluorometric Assay Kit

K122-100 each
EUR 523.2

Caspase-5 Fluorometric Assay Kit

K122-200 each
EUR 698.4

Caspase-5 Fluorometric Assay Kit

K122-25 each
EUR 242.4

Caspase-5 Fluorometric Assay Kit

K122-400 each
EUR 1149.6

Caspase-4 Fluorometric Assay Kit

K126-100 each
EUR 561.6

Caspase-4 Fluorometric Assay Kit

K126-200 each
EUR 738

Caspase-4 Fluorometric Assay Kit

K126-25 each
EUR 255.6

Caspase-4 Fluorometric Assay Kit

K126-400 each
EUR 1110

Caspase-5 Fluorometric Assay Kit

K2195-100 100 assays
EUR 571
Description: Convenient, Highly-Sensitive Assay.

Caspase-5 Fluorometric Assay Kit

K2195-200 200 assays
EUR 835.2

Caspase-5 Fluorometric Assay Kit

K2195-25 25 assays
EUR 285.6

Caspase-5 Fluorometric Assay Kit

K2195-400 400 assays
EUR 1336.8

Caspase-4 Fluorometric Assay Kit

K2198-100 100 assays
EUR 562
Description: Convenient, Highly-Sensitive Assay.

Caspase-4 Fluorometric Assay Kit

K2198-200 200 assays
EUR 885.6

Caspase-4 Fluorometric Assay Kit

K2198-25 25 assays
EUR 301.2

Caspase-4 Fluorometric Assay Kit

K2198-400 400 assays
EUR 1336.8

Caspase-3 Fluorometric Assay kit

TBS2035 100 tests
EUR 289

Caspase-1 Fluorometric Assay kit

TBS2045 100 tests
EUR 289

Caspase-12 Fluorometric Assay Kit

GWB-AXR105 100 assays Ask for price

Caspase-12 Fluorometric Assay Kit

GWB-AXR106 25 assays Ask for price

Caspase-12 Fluorometric Assay Kit

K139-100 each
EUR 601.2

Caspase-12 Fluorometric Assay Kit

K139-25 each
EUR 307.2

Caspase-10 Fluorometric Assay Kit

K124-100 each
EUR 529.2

Caspase-10 Fluorometric Assay Kit

K124-200 each
EUR 738

Caspase-10 Fluorometric Assay Kit

K124-25 each
EUR 242.4

Caspase-10 Fluorometric Assay Kit

K124-400 each
EUR 1149.6

Caspase-12 Fluorometric Assay Kit

K2150-100 100 assays
EUR 571
Description: Detects ATAD-dependent caspase-12 activity, highly sensitive.

Caspase-12 Fluorometric Assay Kit

K2150-25 25 assays
EUR 301.2

Genorise® Caspase-6 Fluorometric Assay Kit

GR107024 100 tests
EUR 289

Caspase-3 DEVD-R110 Fluorometric and Colorimetric Assay Kit (100 assays)

30008-2 1KIT
EUR 459.6
Description: Minimum order quantity: 1 unit of 1KIT

Caspase-8 IETD-R110 Fluorometric and Colorimetric Assay Kit (100 assays)

30011-2 1KIT
EUR 459.6
Description: Minimum order quantity: 1 unit of 1KIT

Caspase-Family Fluorometric Assay kit

TBS2055 9x25 tests
EUR 589

Genorise® Caspase-3 Fluorometric Assay Kit

GR107006 100 tests
EUR 350

Genorise® Caspase-1 Fluorometric Assay Kit

GR107008 100 tests
EUR 350

Genorise® Caspase-2 Fluorometric Assay Kit

GR107018 100 tests
EUR 289

Genorise® Caspase-4 Fluorometric Assay Kit

GR107020 100 tests
EUR 289

Genorise® Caspase-5 Fluorometric Assay Kit

GR107022 100 tests
EUR 289

Genorise® Caspase-8 Fluorometric Assay Kit

GR107026 100 tests
EUR 289

Genorise® Caspase-9 Fluorometric Assay Kit

GR107028 100 tests
EUR 289

Genorise® Caspase-10 Fluorometric Assay Kit

GR107030 100 tests
EUR 289

Caspase-8, 10 Activity Fluorometric Assay Kit

RP10238K 1kit
EUR 552.5

Caspase-3, 7 Activity Fluorometric Assay Kit

RP10240K 1kit
EUR 552.5

Caspase-3 Activity Assay Kit II (Fluorometric)

K533-100 each
EUR 614.4

Caspase-3 DEVD-R110 Fluorometric HTS Assay Kit

30009-1 1KIT
EUR 56
Description: N/A

Caspase-3 DEVD-R110 Fluorometric HTS Assay Kit

30009-1-1 KT
EUR 56

Caspase-3 DEVD-R110 Fluorometric HTS Assay Kit

30009-2 1KIT
EUR 199
Description: N/A

Caspase-3 DEVD-R110 Fluorometric HTS Assay Kit

30009-2-1 KT
EUR 199

Caspase-3 DEVD-R110 Fluorometric HTS Assay Kit

30009-3 1KIT
EUR 854
Description: N/A

Caspase-3 DEVD-R110 Fluorometric HTS Assay Kit

30009-3-1 KT
EUR 854

Caspase-8 IETD-R110 Fluorometric HTS Assay Kit

30012-1 1KIT
EUR 120
Description: Minimum order quantity: 1 unit of 1KIT

Caspase-8 IETD-R110 Fluorometric HTS Assay Kit

30012-2 1KIT
EUR 429.6
Description: Minimum order quantity: 1 unit of 1KIT

Caspase-8 IETD-R110 Fluorometric HTS Assay Kit

30012-3 1KIT
EUR 1952.4
Description: Minimum order quantity: 1 unit of 1KIT

Caspae-9 Activity Fluorometric Assay Kit

RP10239K 1kit
EUR 552.5

GST Fluorometric Assay Kit

55R-1350 100 assays
EUR 513
Description: Assay Kit for detection of GST activity in the research laboratory

NADH Fluorometric Assay Kit

K2037-100 100 assays
EUR 557
Description: Detects NADH, highly sensitive.

HDAC Fluorometric Assay kit

TBS2060 100 tests
EUR 289

Glucose Fluorometric Assay Kit

K2221-100 100 assays
EUR 571
Description: Detects glucose, highly sensitive, high throughput screening (HTS).

Lactate Fluorometric Assay Kit

K2140-100 100 assays
EUR 586
Description: Detects lactate, highly sensitive, high throughput screening (HTS).

Inosine Fluorometric Assay Kit

K712-100 each
EUR 639.6

Ethanol Fluorometric Assay kit

TBS2095 100 tests
EUR 259

Sucrose Fluorometric Assay Kit

E-BC-F042-96T 96T
EUR 350
Description: Quantitative

Sucrose Fluorometric Assay Kit

E-BC-F042-each each Ask for price
Description: Quantitative

Glucose-6-Phosphate Fluorometric Assay Kit

K2220-100 100 assays
EUR 600
Description: Detects glucose-6-phosphate, highly sensitive.

Glycogen Fluorometric Assay Kit

E-BC-F040-500Assays 500 Assays
EUR 1000
Description: Quantitative

Glycogen Fluorometric Assay Kit

E-BC-F040-96T 96T
EUR 425
Description: Quantitative

Glycogen Fluorometric Assay Kit

E-BC-F040-each each Ask for price
Description: Quantitative

Fructose-6-Phosphate Fluorometric Assay Kit

K2222-100 100 assays
EUR 466
Description: Detects fructose-6-phosphate, highly sensitive.

Phosphate Fluorometric Assay Kit

55R-1404 100 assays
EUR 367
Description: Assay Kit for detection of Phosphate in the research laboratory

Phosphate Fluorometric Assay Kit

GWB-AXR232 100 assays Ask for price

Citrulline Fluorometric Assay Kit

K2002-100 each
EUR 744

Zinc Assay Kit (Fluorometric)

K428-100 each
EUR 627.6

The TRPA1 channel is activated by noxious chilly (<17 °C) in addition to by a plethora of chemical compounds that consists of not solely electrophilic compounds and oxidants that can modify, in an alkylative or oxidative vogue, nucleophilic cysteine residues in the channel’s N-terminus, but in addition compounds that don’t covalently bind to the channel proteins (e.g. menthol, nifedipin). Based on localization and purposeful properties, TRPA1 is thought-about a key participant in acute and power (neuropathic) ache and irritation. Moreover, its position in the (patho)physiology of practically all organ methods is anticipated, and will be mentioned alongside with the potential of TRPA1 as a drug goal for the administration of numerous pathological circumstances.

Using chemical shift perturbation to characterise ligand binding.

Using chemical shift perturbation to characterise ligand binding.

Chemical shift perturbation (CSP, chemical shift mapping or complexation-induced modifications in chemical shift, CIS) follows modifications within the chemical shifts of a protein when a ligand is added, and makes use of these to decide the placement of the binding web site, the affinity of the ligand, and/or presumably the construction of the advanced. A key consider figuring out the looks of spectra throughout a titration is the change price between free and certain, or extra particularly the off-rate koff. When koff is bigger than the chemical shift distinction between free and certain, which generally equates to an affinity Kd weaker than about 3μM, then change is quick on the chemical shift timescale.

Under these circumstances, the noticed shift is the population-weighted common of free and certain, which permits Kd to be decided from measurement of peak positions, offered the measurements are made appropriately. (1)H shifts are influenced to a big extent by through-space interactions, whereas (13) and (13)Cβ shifts are influenced extra by through-bond results. (15)N and (13)C’ shifts are influenced each by through-bond and by through-space (hydrogen bonding) interactions. For figuring out the placement of a certain ligand on the idea of shift change, probably the most acceptable methodology is subsequently normally to measure (15)N HSQC spectra, calculate the geometrical distance moved by the height, weighting (15)N shifts by an element of about 0.14 in contrast to (1)H shifts, and choose these residues for which the weighted shift change is bigger than the usual deviation of the shift for all residues.

Other strategies are mentioned, particularly the measurement of (13)CH3 indicators. Slow to intermediate change charges lead to line broadening, and make Kd values very troublesome to acquire. There isn’t any great way to distinguish modifications in chemical shift due to direct binding of the ligand from modifications in chemical shift due to allosteric change. Ligand binding at a number of websites can typically be characterised, by simultaneous becoming of many measured shift modifications, or extra just by including substoichiometric quantities of ligand. The chemical shift modifications can be utilized as restraints for docking ligand onto protein. By use of quantitative calculations of ligand-induced chemical shift modifications, it’s changing into potential to decide not simply the place but in addition the orientation of ligands.

Glutamate and neurotrophic elements in neuronal plasticity and illness.

Glutamate’s position as a neurotransmitter at synapses has been recognized for 40 years, however glutamate has since been proven to regulate neurogenesis, neurite outgrowth, synaptogenesis, and neuron survival within the creating and grownup mammalian nervous system. Cell-surface glutamate receptors are coupled to Ca(2+) inflow and launch from endoplasmic reticulum shops, which causes speedy (kinase- and protease-mediated) and delayed (transcription-dependent) responses that change the construction and performance of neurons. Neurotrophic elements and glutamate work together to regulate developmental and grownup neuroplasticity. For instance, glutamate stimulates the manufacturing of brain-derived neurotrophic issue (BDNF), which, in flip, modifies neuronal glutamate sensitivity, Ca(2+) homeostasis, and plasticity.

Neurotrophic elements could modify glutamate signaling straight, by altering the expression of glutamate receptor subunits and Ca(2+)-regulating proteins, and likewise not directly by inducing the manufacturing of antioxidant enzymes, energy-regulating proteins, and antiapoptotic Bcl-2 relations. Excessive activation of glutamate receptors, beneath situations of oxidative and metabolic stress, could contribute to neuronal dysfunction and degeneration in ailments starting from stroke and Alzheimer’s illness to psychiatric issues. By enhancing neurotrophic issue signaling, environmental elements comparable to train and dietary vitality restriction, and chemical compounds comparable to antidepressants could optimize glutamatergic signaling and shield in opposition to neurological issues.

Using chemical shift perturbation to characterise ligand binding.

Glial cells in (patho)physiology.

Neuroglial cells outline mind homeostasis and mount protection in opposition to pathological insults. Astroglia regulate neurogenesis and improvement of mind circuits. In the grownup mind, astrocytes enter into intimate dynamic relationship with neurons, particularly at synaptic websites the place they functionally kind the tripartite synapse. At these websites, astrocytes regulate ion and neurotransmitter homeostasis, metabolically help neurons and monitor synaptic exercise; one of many readouts of the latter manifests in astrocytic intracellular Ca(2+) indicators. This type of astrocytic excitability can lead to launch of chemical transmitters by way of Ca(2+) -dependent exocytosis.

Once within the extracellular area, gliotransmitters can modulate synaptic plasticity and trigger modifications in habits. Besides these physiological duties, astrocytes are elementary for development and final result of neurological ailments. In Alzheimer’s illness, for instance, astrocytes could contribute to the etiology of this dysfunction. Highly deadly glial-derived tumors use signaling trickery to coerce regular mind cells to help tumor invasiveness. This evaluation not solely sheds new gentle on the mind operation in well being and illness, but in addition factors to many unknowns.

Caspase 5 p10 Antibody

20-abx009504
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Caspase 5 p10 Antibody

E38PA1145 100ul
EUR 225
Description: Available in various conjugation types.

Caspase 5 p10 antibody

70R-49464 100 ul
EUR 242
Description: Purified Polyclonal Caspase 5 p10 antibody

Caspase 14 p10 antibody

70R-50903 100 ul
EUR 242
Description: Purified Polyclonal Caspase 14 p10 antibody

Caspase 1 (p10, Cleaved-Ala317) Antibody

20-abx015550
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Caspase 1 (p10, Cleaved-Ala317) Antibody

E11-0141L 100μg/100μl
EUR 225
Description: Available in various conjugation types.

Polyclonal Anti- Caspase-3 (P10) Antibody

GWB-BBP182 0.1 mg Ask for price

OABB00476-100UG - Caspase-1 (p10) Polyclonal Antibody

OABB00476-100UG 100ug
EUR 419

Caspase 14 (p10, Cleaved-Lys222) Antibody

20-abx015552
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Caspase 5 (p10, Cleaved-Ser331) Antibody

20-abx015560
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Caspase 14 (p10, Cleaved-Lys222) Antibody

E11-0148L 100μg/100μl
EUR 225
Description: Available in various conjugation types.

Caspase-3(P10)

PA1302 100μg
EUR 260

Caspase-3 (P10)

PA1302-M 100μg
EUR 290
Description: Polyclonal Antibodies Conjugated to Magnetic Beads

Caspase-3 (P10)

PA1302-S 100μg
EUR 290
Description: Polyclonal Antibodies Conjugated to Sepharose Beads

Rabbit polyclonal Caspase 1 (p10, Cleaved-Ala317) antibody

TA312624 100 µl Ask for price

OABB00478-100UG - Caspase-8 (P10) Polyclonal Antibody

OABB00478-100UG 100ug
EUR 419

Caspase 1 p10 Blocking Peptide

20-abx062325
  • Ask for price
  • Ask for price
  • 1 mg
  • 5 mg

Caspase 5 Subunit p10 Cleaved-Ser331 (CASP5 p10 Cleaved-S331) Antibody

abx015560-1mg 1 mg
EUR 43.75

Caspase 14 Subunit p10 Cleaved-Lys222 (CASP14 p10 Cleaved-Ks222) Antibody

abx015552-1mg 1 mg
EUR 43.75

Rabbit polyclonal Caspase 14 (p10, Cleaved-Lys222) antibody

TA312750 100 µl Ask for price

Caspase 5 p10 Blocking Peptide

20-abx062339
  • Ask for price
  • Ask for price
  • 1 mg
  • 5 mg

Caspase 14 p10 Blocking Peptide

20-abx063778
  • Ask for price
  • Ask for price
  • 1 mg
  • 5 mg

Rat Caspase-1 subunit p10 ELISA Kit

E01A12807 96T
EUR 700
Description: ELISA

Goat Caspase-1 subunit p10 ELISA Kit

E01A47717 96T
EUR 700
Description: ELISA

Mouse Caspase-1 subunit p10 ELISA Kit

E01A21548 96T
EUR 700
Description: ELISA

Human Caspase-1 subunit p10 ELISA Kit

E01A4044 96T
EUR 700
Description: ELISA

Sheep Caspase-1 subunit p10 ELISA Kit

E01A100011 96T
EUR 700
Description: ELISA

Caspase 1 Subunit 10 Cleaved-Ala317 (CASP1 p10 Cleaved-A317) Antibody

abx015550-1mg 1 mg
EUR 43.75

Canine Caspase-1 subunit p10 ELISA Kit

E01A65149 96T
EUR 700
Description: ELISA

Monkey Caspase-1 subunit p10 ELISA Kit

E01A73863 96T
EUR 700
Description: ELISA

Rabbit Caspase-1 subunit p10 ELISA Kit

E01A30285 96T
EUR 700
Description: ELISA

Bovine Caspase-1 subunit p10 ELISA Kit

E01A82582 96T
EUR 700
Description: ELISA

Porcine Caspase-1 subunit p10 ELISA Kit

E01A56434 96T
EUR 700
Description: ELISA

Chicken Caspase-1 subunit p10 ELISA Kit

E01A91304 96T
EUR 700
Description: ELISA

Cleaved Caspase-1 (Arg317) /P10 Blocking Peptide

AF4022-BP 1mg
EUR 234

Caspase 1 p20 Antibody

20-abx009515
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Caspase 1 p20 antibody

70R-49453 100 ul
EUR 242
Description: Purified Polyclonal Caspase 1 p20 antibody

Guinea Pig Caspase-1 subunit p10 ELISA Kit

E01A38999 96T
EUR 700
Description: ELISA

Rat Caspase-8 subunit p10 ELISA kit

E01A12785 96T
EUR 700
Description: ELISA

Rat Caspase-9 subunit p10 ELISA kit

E01A12787 96T
EUR 700
Description: ELISA

Goat Caspase-8 subunit p10 ELISA kit

E01A47696 96T
EUR 700
Description: ELISA

Goat Caspase-9 subunit p10 ELISA kit

E01A47698 96T
EUR 700
Description: ELISA

Caspase-1 Antibody (p20)

R30510 100 ug
EUR 356.15
Description: Caspase-1 is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta, interleukin 18, and interleukin 33 precursor proteins. The Caspase-1 gene consists of 10 exons spanning at least 10.6 kb and is mapped to 11q23, a site frequently involved in rearrangement in human cancers, including a number of leukemias and lymphomas.

Caspase-1 Antibody (p20)

R30511 100 ug
EUR 356.15
Description: Caspase-1 is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta, IL-18, and IL-33 precursor proteins. It belongs to a family of cysteine proteases known as caspases that always cleave proteins following an aspartic acid residue. The Caspase-1 gene consists of 10 exons spanning at least 10.6 kb and is mapped to 11q23, a site frequently involved in rearrangement in human cancers, including a number of leukemias and lymphomas, by Southern DNA blot analysis of rodent-human hybrids and by in situ hybridization to normal human metaphase chromosomes. Caspase 1 has been shown to induce cell necrosis or pyroptosis and may function in various developmental stages.

Caspase 4 (p10, Cleaved-Ala290) rabbit pAb

E28PC0119 100μl
EUR 255
Description: Available in various conjugation types.

Caspase 4 (p10, Cleaved-Ala290) rabbit pAb

E44H11401 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Mouse Caspase-8 subunit p10 ELISA kit

E01A21526 96T
EUR 700
Description: ELISA

Mouse Caspase-9 subunit p10 ELISA kit

E01A21528 96T
EUR 700
Description: ELISA

Human Caspase-8 subunit p10 ELISA kit

E01A4023 96T
EUR 700
Description: ELISA

Human Caspase-9 subunit p10 ELISA kit

E01A4025 96T
EUR 700
Description: ELISA

Sheep Caspase-8 subunit p10 ELISA kit

E01A99990 96T
EUR 700
Description: ELISA

Sheep Caspase-9 subunit p10 ELISA kit

E01A99992 96T
EUR 700
Description: ELISA

Canine Caspase-8 subunit p10 ELISA kit

E01A65128 96T
EUR 700
Description: ELISA

Canine Caspase-9 subunit p10 ELISA kit

E01A65130 96T
EUR 700
Description: ELISA

Monkey Caspase-8 subunit p10 ELISA kit

E01A73842 96T
EUR 700
Description: ELISA

Monkey Caspase-9 subunit p10 ELISA kit

E01A73844 96T
EUR 700
Description: ELISA

Rabbit Caspase-8 subunit p10 ELISA kit

E01A30263 96T
EUR 700
Description: ELISA

Rabbit Caspase-9 subunit p10 ELISA kit

E01A30265 96T
EUR 700
Description: ELISA

Bovine Caspase-8 subunit p10 ELISA kit

E01A82561 96T
EUR 700
Description: ELISA

Bovine Caspase-9 subunit p10 ELISA kit

E01A82563 96T
EUR 700
Description: ELISA

Porcine Caspase-8 subunit p10 ELISA kit

E01A56413 96T
EUR 700
Description: ELISA

Porcine Caspase-9 subunit p10 ELISA kit

E01A56415 96T
EUR 700
Description: ELISA

Chicken Caspase-8 subunit p10 ELISA kit

E01A91283 96T
EUR 700
Description: ELISA

Chicken Caspase-9 subunit p10 ELISA kit

E01A91285 96T
EUR 700
Description: ELISA

Hamster Caspase-8 subunit p10 ELISA kit

E01A104825 96T
EUR 700
Description: ELISA

Hamster Caspase-9 subunit p10 ELISA kit

E01A104827 96T
EUR 700
Description: ELISA

Caspase-1 Antibody

24290-100ul 100ul
EUR 468

Caspase-1 Antibody

24291-100ul 100ul
EUR 468

Caspase-1 Antibody

3019-100 each
EUR 483.6

Caspase-1 Antibody

3019-30T each
EUR 175.2

Caspase-1 Antibody

48847-100ul 100ul
EUR 399.6

Caspase-1 Antibody

48847-50ul 50ul
EUR 286.8

Caspase-1 Antibody

3459-002mg 0.02 mg
EUR 206.18
Description: Caspase-1 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1β and IL-18. Caspase-1 was initially identified as an IL-1β-converting enzyme; later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 whose overexpression can induce apoptosis in fibroblasts.

Caspase-1 Antibody

3459-01mg 0.1 mg
EUR 523.7
Description: Caspase-1 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1β and IL-18. Caspase-1 was initially identified as an IL-1β-converting enzyme; later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 whose overexpression can induce apoptosis in fibroblasts.

Caspase-1 Antibody

3463-002mg 0.02 mg
EUR 206.18
Description: Caspase-1 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1β and IL-18. Caspase-1 was initially identified as an IL-1β-converting enzyme; later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 whose overexpression can induce apoptosis in fibroblasts.

Caspase-1 Antibody

3463-01mg 0.1 mg
EUR 523.7
Description: Caspase-1 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1β and IL-18. Caspase-1 was initially identified as an IL-1β-converting enzyme; later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 whose overexpression can induce apoptosis in fibroblasts.

Guinea Pig Caspase-8 subunit p10 ELISA kit

E01A38978 96T
EUR 700
Description: ELISA

Guinea Pig Caspase-9 subunit p10 ELISA kit

E01A38980 96T
EUR 700
Description: ELISA

Caspase 9 p35 Antibody

20-abx121860
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Caspase 3 p12 Antibody

20-abx141269
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Caspase 9 p35 Antibody

20-abx141270
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Caspase 8 p18 Antibody

20-abx133383
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Caspase 4 p20 Antibody

20-abx007564
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Caspase 7 p11 Antibody

20-abx009499
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Caspase 6 p18 Antibody

20-abx009501
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Caspase 6 p18 Antibody

20-abx009502
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Caspase 5 p20 Antibody

20-abx009503
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Caspase 4 p20 Antibody

20-abx009505
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Caspase 3 p17 Antibody

20-abx009507
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Caspase 3 p17 Antibody

20-abx009508
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Caspase 3 p17 Antibody

20-abx009509
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Caspase 2 p18 Antibody

20-abx009513
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Caspase 2 p18 Antibody

20-abx009514
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Caspase 7 p20 Antibody

E38PA6277 100ul
EUR 225
Description: Available in various conjugation types.

Caspase 8 p18 Antibody

E38PA6278 100ul
EUR 225
Description: Available in various conjugation types.

Caspase 2 p18 Antibody

E38PA1136 100ul
EUR 225
Description: Available in various conjugation types.

Caspase 3 p17 Antibody

E38PA1141 100ul
EUR 225
Description: Available in various conjugation types.

Caspase 3 p17 Antibody

E38PA1142 100ul
EUR 225
Description: Available in various conjugation types.

Caspase 5 p20 Antibody

E38PA1146 100ul
EUR 225
Description: Available in various conjugation types.

Caspase 6 p18 Antibody

E38PA1147 100ul
EUR 225
Description: Available in various conjugation types.

Caspase 6 p18 Antibody

E38PA1148 100ul
EUR 225
Description: Available in various conjugation types.

Caspase 2 p18 antibody

70R-49454 100 ul
EUR 242
Description: Purified Polyclonal Caspase 2 p18 antibody

Caspase 2 p18 antibody

70R-49455 100 ul
EUR 242
Description: Purified Polyclonal Caspase 2 p18 antibody

Caspase 3 p17 antibody

70R-49459 100 ul
EUR 242
Description: Purified Polyclonal Caspase 3 p17 antibody

Caspase 3 p17 antibody

70R-49460 100 ul
EUR 242
Description: Purified Polyclonal Caspase 3 p17 antibody

Caspase 3 p17 antibody

70R-49461 100 ul
EUR 242
Description: Purified Polyclonal Caspase 3 p17 antibody

Caspase 4 p20 antibody

70R-49463 100 ul
EUR 242
Description: Purified Polyclonal Caspase 4 p20 antibody

Caspase 5 p20 antibody

70R-49465 100 ul
EUR 242
Description: Purified Polyclonal Caspase 5 p20 antibody

Caspase 6 p18 antibody

70R-49466 100 ul
EUR 242
Description: Purified Polyclonal Caspase 6 p18 antibody

Caspase 6 p18 antibody

70R-49467 100 ul
EUR 242
Description: Purified Polyclonal Caspase 6 p18 antibody

Caspase 7 p11 antibody

70R-49469 100 ul
EUR 242
Description: Purified Polyclonal Caspase 7 p11 antibody

Caspase 4 p20 antibody

70R-51475 100 ul
EUR 242
Description: Purified Polyclonal Caspase 4 p20 antibody

Caspase-6 p18 Antibody

49099 100ul
EUR 499

Caspase-6 p18 Antibody

49099-100ul 100ul
EUR 399.6

Caspase-6 p18 Antibody

49099-50ul 50ul
EUR 286.8

Caspase 1 Antibody

6687-100 each
EUR 405.6

Caspase 1 Antibody

6687-30T each
EUR 175.2

Caspase 1 antibody

20R-1427 100 ug
EUR 781.2
Description: Rabbit polyclonal Caspase 1 antibody

caspase 1 Antibody

39310-100ul 100ul
EUR 468

Caspase 1 Antibody

E18-5418-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

Caspase 1 Antibody

E18-5418-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

Caspase 1 Antibody

DF6148 200ul
EUR 420

Caspase 1 Antibody

DF6148-100ul 100ul
EUR 280

Caspase 1 Antibody

DF6148-200ul 200ul
EUR 350

Caspase 1 Antibody

E38PA5426 100ul
EUR 225
Description: Available in various conjugation types.

Caspase 1 Antibody

E38PA1133 100ul
EUR 225
Description: Available in various conjugation types.

caspase 1 Antibody

E300022a 100ug/200ul
EUR 275
Description: Available in various conjugation types.

caspase 1 Antibody

E300022b 200ul
EUR 275
Description: Available in various conjugation types.

Caspase 1 antibody

CAF50447-100ug 100ug
EUR 338

Caspase 1 antibody

CAF50515-100ug 100ug
EUR 338

Caspase 1 antibody

70R-13979 100 ug
EUR 519
Description: Affinity purified Rabbit polyclonal Caspase 1 antibody

Caspase 1 antibody

70R-14061 100 ug
EUR 519
Description: Affinity purified Rabbit polyclonal Caspase 1 antibody

Caspase 1 antibody

70R-15367 100 ug
EUR 302
Description: Rabbit polyclonal Caspase 1 antibody

Caspase 1 antibody

70R-11561 100 ug
EUR 490
Description: Rabbit polyclonal Caspase 1 antibody

Caspase 1 antibody

70R-31086 100 ug
EUR 294
Description: Rabbit polyclonal Caspase 1 antibody

Caspase 1 antibody

70R-31087 100 ug
EUR 294
Description: Rabbit polyclonal Caspase 1 antibody

Caspase 1 antibody

70R-31116 100 ug
EUR 294
Description: Rabbit polyclonal Caspase 1 antibody

Caspase 1 antibody

70R-35920 100 ug
EUR 294
Description: Rabbit polyclonal Caspase 1 antibody

Caspase 1 antibody

70R-49451 100 ul
EUR 242
Description: Purified Polyclonal Caspase 1 antibody

Caspase 1 antibody

70R-49452 100 ul
EUR 242
Description: Purified Polyclonal Caspase 1 antibody

A brand new program, TALOS-N, is launched for predicting protein spine torsion angles from NMR chemical shifts. The program depends much more extensively on the usage of educated synthetic neural networks than its predecessor, TALOS+. Validation on an impartial set of proteins indicates that spine torsion angles can be predicted for a bigger, ≥90 % fraction of the residues, with an error price smaller than ca 3.5 %, utilizing an acceptance criterion that’s practically two-fold tighter than that used beforehand, and a root imply sq. distinction between predicted and crystallographically noticed (ϕ, ψ) torsion angles of ca 12º. TALOS-N additionally reviews sidechain χ(1) rotameric states for about 50 % of the residues, and a consistency with reference constructions of 89 %.

Interaction of tRNA with 23S rRNA in the ribosomal A, P, and E sites.

Interaction of tRNA with 23S rRNA in the ribosomal A, P, and E sites.

Three units of conserved nucleotides in 23 rRNA are shielded from chemical probes by binding of tRNA to the ribosomal A, P, and E websites, respectively. They are situated nearly solely in area V, primarily in or adjoining to the loop recognized with the peptidyl transferase operate. Some of these websites are additionally protected by antibiotics equivalent to chloramphenicol, which might clarify how these medicine intervene with protein synthesis. Certain tRNA-dependent protections are abolished when the 3′-terminal A or CA or 2′,3′-linked acyl group is eliminated, offering direct proof for the interplay of the conserved CCA terminus of tRNA with 23S rRNA.

When the EF-Tu.GTP.aminoacyl-tRNA ternary advanced is sure to the ribosome, no tRNA-dependent A web site protections are detected in 23S rRNA till EF-Tu is launched. Thus, EF-Tu prevents interplay of the 3′ terminus of the incoming aminoacyl-tRNA with the peptidyl transferase area of the ribosome throughout anticodon choice, thereby allowing translational proofreading. Some PLTS cells appeared to have two axonal origins from the somata and dendrites. LA cells had been principally massive aspiny cells with Ca(2+)-dependent long-lasting afterhyperpolarizations and robust time-dependent hyperpolarizing rectification.

Plants have advanced subtle programs to manage with herbivore challenges. When vegetation understand herbivore-derived bodily and chemical cues, equivalent to elicitors in bugs’ oral secretions and compounds in oviposition fluids, vegetation dramatically reshape their transcriptomes, proteomes, and metabolomes. All these herbivory-induced modifications are mediated by elaborate signaling networks, which embrace receptors/sensors, Ca(2+) influxes, kinase cascades, reactive oxygen species, and phytohormone signaling pathways. Furthermore, herbivory induces protection responses not solely in the wounded areas but additionally in undamaged areas in the attacked leaves and in distal intact (systemic) leaves.

Here, we overview current progress in understanding plant notion of herbivory and oviposition, and the herbivory-induced early signaling occasions and their organic features. We think about the intraspecific phenotypic variety of plant responses to herbivory and focus on the underlying genetic variation. We additionally focus on new instruments and technical challenges in learning plant-herbivore interactions. Our outcomes point out that TRPA1 is an oxidant sensor in sensory neurons, initiating neuronal excitation and subsequent physiological responses in vitro and in vivo.

The impact of cyanide on the efflux of calcium from squid axons.

The common charge fixed for loss of (45)Ca from an unpoisoned squid axon was 1.Eight x 10(-3) min(-1), similar to an efflux of 0.2 p-mole/cm(2) sec.2. The Ca efflux from unpoisoned axons was diminished if exterior calcium was changed with magnesium, or exterior sodium with lithium, choline or dextrose. Replacing each sodium and calcium diminished the efflux to about 40%.3. Cyanide triggered little quick change in Ca efflux however after 1(half of)-2(half of) hr the efflux elevated to 5-15 instances its regular worth. The impact was quickly reversed when cyanide was eliminated.4.

The giant Ca efflux into cyanide was diminished by an element of three when exterior calcium was changed with magnesium and by an extra issue of about six when exterior sodium was changed with lithium.5. The Ca efflux from each poisoned and unpoisoned axons had a Q(10) of 2-3, was not affected by ouabain and was vastly diminished by injecting ethyleneglycol bis (aminoethylether)-N,N’-tetra-acetic acid (EGTA).6. After injecting (45)Ca alongside the axis, the efflux of calcium reached its most rather more quickly in a cyanide-treated axon than in an unpoisoned axon.7. Pre-treatment with cyanide vastly elevated the charge at which calcium was misplaced from axoplasm extruded into flattened dialysis luggage.

The same impact was noticed when cyanide was utilized after extrusion.8. Replacing exterior sodium glutamate with potassium glutamate vastly diminished the loss of (45)Ca from intact axons poisoned with cyanide however had little impact on the loss from extruded axoplasm.9. The charge fixed for loss of the Ca EGTA advanced was about Three x 10(-5) min(-1) for intact axons and 2 x 10(-2) min(-1) for extruded axoplasm.10. A doable clarification of the cyanide impact is that, after poisoning, calcium ions are launched from a retailer and can then change at a better charge with exterior sodium or calcium.11. The experiments counsel that half of the calcium efflux could also be coupled to sodium entry.12. Theoretical equations for ;diffusion and chemical response in a cylinder’ are described in the Appendix.

Interaction of tRNA with 23S rRNA in the ribosomal A, P, and E sites.

TRPA1 is a serious oxidant sensor in murine airway sensory neurons.

Sensory neurons in the airways are finely tuned to answer reactive chemical substances threatening airway operate and integrity. Nasal trigeminal nerve endings are significantly delicate to oxidants shaped in polluted air and throughout oxidative stress in addition to to chlorine, which is steadily launched in industrial and home accidents. Oxidant activation of airway neurons induces respiratory melancholy, nasal obstruction, sneezing, cough, and ache. While usually protecting, chemosensory airway reflexes can provoke extreme issues in sufferers affected by inflammatory airway circumstances like rhinitis and bronchial asthma.

Caspase 9 antibody

20R-2497 50 ug
EUR 269
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 Antibody

21422 100ul
EUR 319

Caspase 9 Antibody

21422-100ul 100ul
EUR 302.4

Caspase 9 Antibody

21422-50ul 50ul
EUR 224.4

Caspase 9 antibody

22978 100ul
EUR 479

Caspase 9 antibody

22978-100ul 100ul
EUR 468

Caspase 9 Antibody

E021422 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Caspase 9 Antibody

E18-6348-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

Caspase 9 Antibody

E18-6348-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

Caspase 9 Antibody

E38PA1155 100ul
EUR 225
Description: Available in various conjugation types.

Caspase 9 Antibody

E38PA1156 100ul
EUR 225
Description: Available in various conjugation types.

Caspase 9 Antibody

E38PA3157 100ul
EUR 225
Description: Available in various conjugation types.

Caspase 9 Antibody

E312193 200ul
EUR 275
Description: Available in various conjugation types.

Caspase 9 Antibody

GWB-12726F 0.5 ml Ask for price

Caspase 9 Antibody

DF7048 200ul
EUR 420

Caspase 9 Antibody

DF7048-100ul 100ul
EUR 280

Caspase 9 Antibody

DF7048-200ul 200ul
EUR 350

Caspase 9 Antibody

E38PA9134 100ul
EUR 225
Description: Available in various conjugation types.

Caspase 9 Antibody

AF6348 200ul
EUR 420

Caspase 9 Antibody

AF6348-100ul 100ul
EUR 280

Caspase 9 Antibody

AF6348-200ul 200ul
EUR 350

Caspase 9 Antibody

AF6870 100ul
EUR 420

Caspase 9 Antibody

AF6870-100ul 100ul
EUR 280

Caspase 9 Antibody

AF6870-200ul 200ul
EUR 350

Caspase 9 antibody

70R-13511 100 ul
EUR 550
Description: Affinity purified Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody

70R-14132 100 ug
EUR 519
Description: Affinity purified Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody

70R-49474 100 ul
EUR 242
Description: Purified Polyclonal Caspase 9 antibody

Caspase 9 antibody

70R-49475 100 ul
EUR 242
Description: Purified Polyclonal Caspase 9 antibody

Caspase 9 antibody

70R-30659 100 ug
EUR 294
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody

70R-31082 100 ug
EUR 294
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody

70R-31083 100 ug
EUR 294
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody

70R-31084 100 ug
EUR 294
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody

70R-33457 100 ug
EUR 294
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody

70R-33459 100 ug
EUR 294
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody

70R-33461 100 ug
EUR 294
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody

70R-11636 100 ug
EUR 357
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody

70R-11806 100 ug
EUR 343
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody

70R-51476 100 ul
EUR 242
Description: Purified Polyclonal Caspase 9 antibody

Caspase 9 antibody

CAF50061-100ug 100ug
EUR 312

Caspase 9 Antibody

ABF6348 100 ug
EUR 525.6

Caspase-9 Antibody

6670-100 each
EUR 405.6

Caspase-9 Antibody

6670-30T each
EUR 175.2

Caspase-9 Antibody

2071-002mg 0.02 mg
EUR 206.18
Description: Caspase-9 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3. Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation. Caspase-9 is also activated by granzyme B and CPP32. Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFα, TRAIL, anti-CD-95, FADD, and TRADD. Caspase-9 is expressed in a variety of human tissues.

Caspase-9 Antibody

2071-01mg 0.1 mg
EUR 523.7
Description: Caspase-9 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3. Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation. Caspase-9 is also activated by granzyme B and CPP32. Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFα, TRAIL, anti-CD-95, FADD, and TRADD. Caspase-9 is expressed in a variety of human tissues.

Caspase-9 Antibody

2073-002mg 0.02 mg
EUR 206.18
Description: Caspase-9 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3. Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation. Caspase-9 is also activated by granzyme B and CPP32. Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFα, TRAIL, anti-CD-95, FADD, and TRADD. Caspase-9 is expressed in a variety of human tissues.

Caspase-9 Antibody

2073-01mg 0.1 mg
EUR 523.7
Description: Caspase-9 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3. Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation. Caspase-9 is also activated by granzyme B and CPP32. Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFα, TRAIL, anti-CD-95, FADD, and TRADD. Caspase-9 is expressed in a variety of human tissues.

Caspase-9 Antibody

24049 100ul
EUR 479

Caspase-9 Antibody

24049-100ul 100ul
EUR 468

Caspase-9 Antibody

24050 100ul
EUR 479

Caspase-9 Antibody

24050-100ul 100ul
EUR 468

Caspase-9 Antibody

3016-100 each
EUR 405.6

Caspase-9 Antibody

3016-30T each
EUR 175.2

Caspase-9 Antibody

3136-100 each
EUR 392.4

Caspase-9 Antibody

3136-30T each
EUR 175.2

Caspase-9 Antibody

3409-100 each
EUR 379.2

Caspase-9 Antibody

3409-30T each
EUR 175.2

Caspase-9 Antibody

48161 100ul
EUR 429

Caspase-9 Antibody

48161-100ul 100ul
EUR 399.6

Caspase-9 Antibody

48161-50ul 50ul
EUR 286.8

Caspase-9 Antibody

48687 100ul
EUR 499

Caspase-9 Antibody

48687-100ul 100ul
EUR 399.6

Caspase-9 Antibody

48687-50ul 50ul
EUR 286.8

Caspase-9 Antibody

49014 100ul
EUR 499

Caspase-9 Antibody

49014-100ul 100ul
EUR 399.6

Caspase-9 Antibody

49014-50ul 50ul
EUR 286.8

Caspase-9 Antibody

F50929-0.08ML 0.08 ml
EUR 140.25
Description: Caspase 9 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade.

Caspase-9 Antibody

F50929-0.4ML 0.4 ml
EUR 322.15
Description: Caspase 9 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade.

Caspase-9 Antibody

F50930-0.08ML 0.08 ml
EUR 140.25
Description: Caspase 9 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade.

Caspase-9 Antibody

F50930-0.4ML 0.4 ml
EUR 322.15
Description: Caspase 9 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade.

Caspase-9 Antibody

RQ6459 100ug
EUR 356.15
Description: CASP9 is also known as MCH6 or APAF3. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.

Caspase-9 Antibody

RQ6974 100 ug
EUR 356.15
Description: CASP9 is also known as MCH6 or APAF3. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.

Caspase-9 Antibody

R30673 100 ug
EUR 356.15
Description: Caspase-9, also called APAF3, is an initiator caspase, encoded by the CASP9 gene. The gene is mapped to chromosome 1p36.3-p36.1 by FISH. CASP9 is identified as a member of the caspase family that participates in CASP3 activation in vitro. And it also regarded as the most upstream member of the apoptotic protease cascade that is triggered by Cytochrome C and dATP. The crystal structure of CASP9 is complex with the BIR3 in an inhibitory domain of XIAP at 2.4-angstrom resolution and the gene contains 9 exons and spans approximately 35 kb of genomic DNA. Caspase-9 and APAF1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of Cytochrome C and dATP, an event that leads to CASP9 activation. Activity increases dramatically upon association with the apoptosome complex. And the majority of CASP9 knockout mice died perinatally with a markedly enlarged and malformed cerebrum caused by reduced apoptosis during brain development.

Caspase-9 Antibody

R31745 100 ug
EUR 356.15
Description: Caspase-9 is also known as MCH6 or APAF3. The CASP9 gene encodes a member of the cysteine-aspartic acid protease family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex ofCytochrome Cand the Apoptotic peptidase activating factor 1. This step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.

pro Caspase 9 Antibody

49230 100ul
EUR 499

pro Caspase 9 Antibody

49230-100ul 100ul
EUR 399.6

pro Caspase 9 Antibody

49230-50ul 50ul
EUR 286.8

anti- Caspase 9 antibody

FNab01295 100µg
EUR 606.3
Description: Antibody raised against Caspase 9

anti- Caspase 9 antibody

FNab01296 100µg
EUR 606.3
Description: Antibody raised against Caspase 9

anti- Caspase 9 antibody

FNab01297 100µg
EUR 658.5
Description: Antibody raised against Caspase 9

Caspase-9 Antibody / CASP9

RQ6371 100 ug
EUR 356.15
Description: CASP9 is also known as MCH6 or APAF3. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.

Caspase-9 Antibody (p35)

RQ5798 100 ug
EUR 356.15
Description: Caspase 9 is an enzyme that in humans is encoded by the CASP9 gene. This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and apoptosis signaling. This protein, the initiator caspase, is activated after cytochrome c release from mitochondria and targets downstream effectors. In mouse, deficiency of this gene can cause perinatal lethality. This protein may have a role in normal brain development. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Caspase 9 antibody (Thr125)

70R-30658 100 ug
EUR 294
Description: Rabbit polyclonal Caspase 9 antibody (Thr125)

Caspase 9 antibody (Tyr153)

70R-33456 100 ug
EUR 294
Description: Rabbit polyclonal Caspase 9 antibody (Tyr153)

Caspase 9 antibody (Ser144)

70R-33458 100 ug
EUR 294
Description: Rabbit polyclonal Caspase 9 antibody (Ser144)

Caspase 9 antibody (Ser196)

70R-33460 100 ug
EUR 294
Description: Rabbit polyclonal Caspase 9 antibody (Ser196)

Active Caspase 9 antibody

70R-11648 100 ug
EUR 567
Description: Rabbit polyclonal Active Caspase 9 antibody

CASP9 Antibody / Caspase-9

RQ6457 100 ug
EUR 356.15
Description: CASP9 is also known as MCH6 or APAF3. This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.

Caspase-9 (CASP9) Antibody

abx402516-100g 100 µg
EUR 287.5

Caspase-9 (CASP9) Antibody

abx341406-100l 100 µl
EUR 350

Caspase-9 (CASP9) Antibody

abx341406-50l 50 µl
EUR 250

Polyclonal Caspase-9 Antibody

APR00030G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-9 . This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-9 Antibody

APR00097G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-9 . This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-9 Antibody

APG02416G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-9 . This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-9 Antibody

APG02417G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-9 . This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-9 Antibody

APG02418G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-9 . This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-9 Antibody

APG02419G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-9 . This antibody is tested and proven to work in the following applications:

Monoclonal Caspase-9 Antibody

APG02420G 0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human Caspase-9. The antibodies are raised in Mouse. This antibody is applicable in WB

Caspase-9 (Active) Antibody

3149-100 each
EUR 614.4

Caspase 9 (CASP9) Antibody

20-abx325040
  • Ask for price
  • Ask for price
  • 100 ug
  • 50 ug

Caspase 9 (CASP9) Antibody

20-abx325109
  • Ask for price
  • Ask for price
  • 100 ug
  • 50 ug

Caspase 9 (CASP9) Antibody

20-abx329576
  • Ask for price
  • Ask for price
  • 100 ug
  • 50 ug

Caspase 9 (CASP9) Antibody

20-abx324591
  • Ask for price
  • Ask for price
  • 100 ug
  • 50 ug

Caspase 9 (CASP9) Antibody

20-abx324794
  • Ask for price
  • Ask for price
  • 100 ug
  • 50 ug

Caspase 9 (CASP9) Antibody

20-abx324822
  • Ask for price
  • Ask for price
  • 100 ug
  • 50 ug

Caspase 9 (CASP9) Antibody

20-abx330233
  • Ask for price
  • Ask for price
  • 100 ug
  • 50 ug

Caspase 9 (CASP9) Antibody

abx330458-100ul 100 ul
EUR 510

Caspase 9 (CASP9) Antibody

abx037417-100ug 100 ug
EUR 469.2

Caspase 9 (CASP9) Antibody

20-abx100471
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Caspase 9 (CASP9) Antibody

20-abx100472
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Caspase 9 (CASP9) Antibody

20-abx100473
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Caspase 9 (CASP9) Antibody

20-abx211450
  • Ask for price
  • Ask for price
  • 100 ul
  • 50 ul

Caspase 9 (CASP9) Antibody

20-abx212408
  • Ask for price
  • Ask for price
  • 100 ul
  • 50 ul

Caspase 9 (CASP9) Antibody

20-abx175721
  • Ask for price
  • Ask for price
  • 1 mg
  • 200 ug

Caspase 9 (CASP9) Antibody

20-abx171616
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Caspase 9 (CASP9) Antibody

20-abx171617
  • Ask for price
  • Ask for price
  • 1 mg
  • 200 ug

Caspase 9 (CASP9) Antibody

20-abx213116
  • Ask for price
  • Ask for price
  • 100 ul
  • 50 ul

Caspase 9 (CASP9) Antibody

20-abx123445
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Caspase 9 (CASP9) Antibody

abx125415-50ul 50 ul
EUR 493.2

Caspase 9 (CASP9) Antibody

20-abx125612
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Caspase 9 (CASP9) Antibody

20-abx128531
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Caspase 9 (CASP9) Antibody

20-abx128921
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Caspase 9 (CASP9) Antibody

abx231295-100ug 100 ug
EUR 577.2

Caspase 9 (CASP9) Antibody

abx231296-100ug 100 ug
EUR 577.2

Caspase 9 (CASP9) Antibody

abx231297-100ug 100 ug
EUR 610.8

Caspase 9 (CASP9) Antibody

20-abx111427
  • Ask for price
  • Ask for price
  • 150 ul
  • 50 ul

Caspase 9 (CASP9) Antibody

20-abx159358
  • Ask for price
  • Ask for price
  • 100 ug
  • 50 ug

Caspase 9 (CASP9) Antibody

20-abx136140
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 50 ul

Caspase 9 (CASP9) Antibody

20-abx134447
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Caspase 9 (CASP9) Antibody

20-abx007563
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Caspase 9 (CASP9) Antibody

20-abx009495
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Caspase 9 (CASP9) Antibody

20-abx009496
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Caspase 9 (CASP9) Antibody

20-abx002046
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Caspase 9 (CASP9) Antibody

abx033801-400ul 400 ul
EUR 627.6

Caspase 9 (CASP9) Antibody

abx033801-80l 80 µl
EUR 343.2

Caspase 9 (CASP9) Antibody

abx033802-400ul 400 ul
EUR 627.6

Caspase 9 (CASP9) Antibody

abx033802-80l 80 µl
EUR 343.2

Caspase 9 (CASP9) Antibody

abx002046-100l 100 µl
EUR 387.5

Caspase 9 (CASP9) Antibody

abx002046-20l 20 µl
EUR 175

Caspase 9 (CASP9) Antibody

abx002046-50l 50 µl
EUR 275

Caspase 9 (CASP9) Antibody

abx231295-100g 100 µg
EUR 350

Caspase 9 (CASP9) Antibody

abx231296-100g 100 µg
EUR 350

Caspase 9 (CASP9) Antibody

abx231297-100g 100 µg
EUR 350

Caspase 9 (CASP9) Antibody

abx243071-96tests 96 tests
EUR 287.5

Caspase 9 (CASP9) Antibody

abx037417-96tests 96 tests
EUR 337.5

Caspase 9 (CASP9) Antibody

abx128531-100l 100 µl
EUR 250

Here, we confirmed that each hypochlorite, the oxidizing mediator of chlorine, and hydrogen peroxide, a reactive oxygen species, activated Ca(2+) inflow and membrane currents in an oxidant-sensitive subpopulation of chemosensory neurons. These responses have been absent in neurons from mice missing TRPA1, an ion channel of the transient receptor potential (TRP) gene household. TRPA1 channels have been strongly activated by hypochlorite and hydrogen peroxide in main sensory neurons and heterologous cells. In exams of respiratory operate, Trpa1(-/-) mice displayed profound deficiencies in hypochlorite- and hydrogen peroxide-induced respiratory melancholy in addition to decreased oxidant-induced ache conduct.

Short-term synaptic plasticity.

Short-term synaptic plasticity.

Synaptic transmission is a dynamic course of. Postsynaptic responses wax and wane as presynaptic exercise evolves. This distinguished attribute of chemical synaptic transmission is an important determinant of the response properties of synapses and, in flip, of the stimulus properties chosen by neural networks and of the patterns of exercise generated by these networks. This evaluation focuses on synaptic modifications that outcome from prior exercise within the synapse below research, and is restricted to short-term results that final for at most a couple of minutes.

Forms of synaptic enhancement, equivalent to facilitation, augmentation, and post-tetanic potentiation, are normally attributed to results of a residual elevation in presynaptic [Ca(2+)]i, appearing on a number of molecular targets that seem like distinct from the secretory set off chargeable for quick exocytosis and phasic launch of transmitter to single motion potentials. We talk about the proof for this speculation, and the origins of the totally different kinetic phases of synaptic enhancement, in addition to the interpretation of statistical modifications in transmitter launch and roles performed by different elements equivalent to alterations in presynaptic Ca(2+) inflow or postsynaptic ranges of [Ca(2+)]i. Synaptic melancholy dominates enhancement at many synapses.

Depression is normally attributed to depletion of some pool of readily releasable vesicles, and numerous types of the depletion mannequin are mentioned. Depression may come up from suggestions activation of presynaptic receptors and from postsynaptic processes equivalent to receptor desensitization. In addition, glial-neuronal interactions can contribute to short-term synaptic plasticity. Finally, we summarize the current literature on putative molecular gamers in synaptic plasticity and the consequences of genetic manipulations and different modulatory influences.

Primary construction of the Aequorea victoria green-fluorescent protein.

Many cnidarians make the most of green-fluorescent proteins (GFPs) as energy-transfer acceptors in bioluminescence. GFPs fluoresce in vivo upon receiving vitality from both a luciferase-oxyluciferin excited-state advanced or a Ca(2+)-activated phosphoprotein. These extremely fluorescent proteins are distinctive because of the chemical nature of their chromophore, which is comprised of modified amino acid (aa) residues throughout the polypeptide. This report describes the cloning and sequencing of each cDNA and genomic clones of GFP from the cnidarian, Aequorea victoria.

The gfp10 cDNA encodes a 238-aa-residue polypeptide with a calculated Mr of 26,888. Comparison of A. victoria GFP genomic clones reveals three totally different restriction enzyme patterns which means that at the least three totally different genes are current within the A. victoria inhabitants at Friday Harbor, Washington. The gfp gene encoded by the lambda GFP2 genomic clone is comprised of at the least three exons unfold over 2.6 kb. The nucleotide sequences of the cDNA and the gene will help within the elucidation of structure-function relationships on this distinctive class of proteins.

Citations in CAS SciFinder to the rule-of-five (RO5) publication will exceed 1000 by year-end 2004. Trends within the RO5 literature explosion that may be discerned are the additional definitions of drug-like. This matter is explored when it comes to drug-like physicochemical options, drug-like structural options, a comparability of drug-like and non-drug-like in drug discovery and a dialogue of how drug-like options relate to medical success. Physicochemical options of CNS medicine and options associated to CNS blood-brain transporter affinity are briefly reviewed. Recent literature on options of non-oral medicine is reviewed and the way options of lead-like compounds differ from these of drug-like compounds is mentioned.

Short-term synaptic plasticity.

In vitro molecular mechanisms of bisphenol A motion.

Bisphenol A (BPA, 2,2-bis (4-hydroxyphenyl) propane; CAS# 80-05-7) is a chemical used primarily within the manufacture of polycarbonate plastic, epoxy resins and as a non-polymer additive to different plastics. Recent proof has demonstrated that human and wildlife populations are uncovered to ranges of BPA which trigger adversarial reproductive and developmental results in various totally different wildlife species and laboratory animal fashions. However, there are main uncertainties surrounding the spectrum of BPA’s mechanisms of motion, the tissue-specific impacts of exposures, and the essential home windows of susceptibility throughout which goal tissues are delicate to BPA exposures.

As a basis to handle a few of these uncertainties, this evaluation was ready by the “In vitro” professional sub-panel assembled in the course of the “Bisphenol A: An Examination of the Relevance of Ecological, In vitro and Laboratory Animal Studies for Assessing Risks to Human Health” workshop held in Chapel Hill, NC, Nov 28-29, 2006. The particular cost of this professional panel was to evaluation and assess the energy of the revealed literature pertaining to the mechanisms of BPA motion. The ensuing doc is an in depth evaluation of revealed research which have centered on the mechanistic foundation of BPA motion in various experimental fashions and an evaluation of the energy of the proof relating to the revealed BPA analysis.

In its present state, the database employs an easy-to-use, searchable interface for acquiring detailed information on the 109 at present recognized RNA modifications. Each entry gives the chemical construction, frequent identify and image, elemental composition and mass, CA registry numbers and index identify, phylogenetic supply, sort of RNA species wherein it’s discovered, and references to the primary reported construction willpower and synthesis. Though newly transferred in its entirety to The RNA Institute, the RNAMDB continues to develop with two notable additions, agmatidine and 8-methyladenosine, appended within the final 12 months.

Anti-CD19-ScFv-CD28-CD3ζ (no marker)

LVP1449 1x10^8 IFU/ml x 200ul
EUR 455
Description: Anti-CD19 CAR Lentivirus with human CD28 stimulatory domain, do not contain any selection marker.

CAR negative control: Anti-CD19-ScFv- CD28 (Puro)

CAR-ctr4 1x10^8 IFU/ml x 200ul
EUR 276.5
Description: Anti-CD19 (CD28) CAR control lentivirus without activation domain, containing Puromycin selection

Anti-CD19-ScFv-4-1BB-CD3ζ (Bsd)

LVP1441 1x10^8 IFU/ml x 200ul
EUR 455
Description: Anti-CD19 CAR Lentivirus with human 4-1BB (CD137) stimulatory domain, containing Blasticidin selection

Anti-CD19-ScFv-4-1BB-CD3ζ (Puro)

LVP1440 1x10^8 IFU/ml x 200ul
EUR 455
Description: Anti-CD19 CAR Lentivirus with human 4-1BB (CD137) stimulatory domain, containing Puromycin selection.

Anti-CD19-ScFv-4-1BB-CD3ζ (no marker)

LVP1444 1x10^8 IFU/ml x 200ul
EUR 455
Description: Anti-CD19 CAR Lentivirus with human 4-1BB (CD137) stimulatory domain, do not contain any selection marker.

Anti-CD19-ScFv-4-1BB-CD3ζ (GFP-Puro)

LVP1442 1x10^8 IFU/ml x 200ul
EUR 455
Description: Anti-CD19 CAR Lentivirus with human 4-1BB (CD137) stimulatory domain, containing GFP-Puromycin dual selection.

Anti-CD19-ScFv-4-1BB-CD3ζ (RFP-Puro)

LVP1443 1x10^8 IFU/ml x 200ul
EUR 455
Description: Anti-CD19 CAR Lentivirus with human 4-1BB (CD137) stimulatory domain, containing RFP-Puromycin dual selection.

CAR negative control: Anti-CD19-ScFv-4-1BB (Puro)

CAR-ctr2 1x10^8 IFU/ml x 200ul
EUR 276.5
Description: Anti-CD19 (4-1BB) control lentivirus without activation domain, containing Puromycin selection

Anti-CD19_CD20-ScFv- CD28-CD3ζ (Puro) Lentivirus

LVP1645 1x10^8 IFU/ml x 200ul
EUR 553
Description: Bispecific Anti-CD19/CD20 CAR Lentivirus with human CD28 stimulatory domain, containing puromycin antibiotic selection

Anti-CD19_CD20-ScFv- CD28-CD3ζ (No Select) Lentivirus

LVP1644 1x10^8 IFU/ml x 200ul
EUR 553
Description: Bispecific Anti-CD19/CD20 CAR Lentivirus with human CD28 stimulatory domain, do not contain antibiotic selection

Anti-CD19_CD20-ScFv- CD28-CD3ζ (GFP-Puro) Lentivirus

LVP1646 1x10^8 IFU/ml x 200ul
EUR 553
Description: Bispecific Anti-CD19/CD20 CAR Lentivirus with human CD28 stimulatory domain, containing GFP-Puromycin dual selection

Anti-CD19 CAR / NFAT (Luciferase) Reporter Jurkat Cell Line (CD19 SCFV-CD28-4-1BB-CD3ζ)

79853 2 vials
EUR 10340
Description: Anti-CD19 CAR/NFAT-luciferase reporter Jurkat cell line is a double stable cell line expressing anti-CD19 CAR and NFAT-luciferase reporter. It is made from the anti-CD19 CAR lentivirus (BPS Bioscience #79851). The reporter cell line has been validated for anti CD19-CAR expression by FACS, and for luciferase reporter activation stimulated by target cells including CD19/CHO recombinant cell line can be used for primary screening and functional validation of anti-CD19 CAR construct and lentivirus before testing in primary T cells.

Anti-CD19 CAR consists of anti-CD19 scFv linked to 3rd generation CAR (Chimeric Antigen Receptor) containing CD28, 4-1BB co-stimulatory domains, and CD3ζ signaling domain.

Anti-CD19_CD20-ScFv-4-1BB-CD3ζ (Puro) Lentivirus

LVP1642 1x10^8 IFU/ml x 200ul
EUR 553
Description: Bispecific Anti-CD19/CD20 CAR Lentivirus with human 4-1BB (CD137) stimulatory domain, containing puromycin antibiotic selection

Anti-CD19_CD20-ScFv-4-1BB-CD3ζ (No Select) Lentivirus

LVP1641 1x10^8 IFU/ml x 200ul
EUR 553
Description: Bispecific Anti-CD19/CD20 CAR Lentivirus with human 4-1BB (CD137) stimulatory domain, do not contain antibiotic selection

Anti-CD19_CD20-ScFv-4-1BB-CD3ζ (GFP-Puro) Lentivirus

LVP1643 1x10^8 IFU/ml x 200ul
EUR 553
Description: Bispecific Anti-CD19/CD20 CAR Lentivirus with human 4-1BB (CD137) stimulatory domain, containing GFP-Puromycin dual selection

Anti-CD19 CAR Lentivirus (CD19 ScFv-CD8-4-1BB-CD3ζ)

78600 50 µl
EUR 1150
Description: The anti-CD19 CAR lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. These viruses constitutively express the ScFv portion of anti-CD19 (clone FMC63) linked to 2nd generation CAR (Chimeric Antigen Receptor) containing CD8 hinge, 4-1BB, and CD3ζ signaling domains. 

Anti-CD28 Antibody [CD28.2], PE-25Tests

QAB37-PE-25Tests 25Tests
EUR 169.2

Anti-CD28 Antibody [CD28.2], APC-25Tests

QAB37-APC-25Tests 25Tests
EUR 188.4

Anti-CD28 Antibody [CD28.2], PE-100Tests

QAB37-PE-100Tests 100Tests
EUR 270

Anti-CD28 Antibody [CD28.2], APC-100Tests

QAB37-APC-100Tests 100Tests
EUR 310.8

Anti-CD28 Antibody [CD28.2], FITC-25Tests

QAB37-F-25Tests 25Tests
EUR 157.2

Anti-CD28 Antibody [CD28.2], FITC-100Tests

QAB37-F-100Tests 100Tests
EUR 240

Anti-CD28 Antibody [CD28.2], Qfluor 630-100ug

QAB37-QF630-100ug 100ug
EUR 259.2

Anti-CD28 Antibody [CD28.2], Unconjugated-100ug

QAB37-100ug 100ug
EUR 169.2

Anti-CD19 CAR Lentivirus (CD19 ScFv-CD8-4-1BB-CD3ζ; SIN Vector)

78601 50 µl
EUR 1150
Description: The anti-CD19 CAR lentiviruses are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. These viruses transduce the ScFv portion of anti-CD19 (clone FMC63) linked to 2nd generation CAR (Chimeric Antigen Receptor) containing CD8 hinge and transmembrane domains, 4-1BB and CD3ζ signaling domains .Note: This product transduces the same construct as the anti-CD19 CAR Lentivirus (CD19 ScFv-CD8-4-1BB-CD3ζ) (BPS Bioscience #78600), but differs in key aspects:78601 is constructed with a SIN lentivector while 78600 is not. 78601 does not contain an antibiotic for selection while 78600 contains a puromycin selection so the transduced cells can be selected with puromycin.

Anti-CD28 Antibody [CD28.2], PE-Cy7-25Tests

QAB37-PE7-25Tests 25Tests
EUR 199.2

Anti-CD28 Antibody [CD28.2], PerCP-Cy5.5-100Tests

QAB37-PCP55-100Tests 100Tests
EUR 381.6

Anti-CD28 Antibody [CD28.2], PerCP-Cy5.5-25Tests

QAB37-PCP55-25Tests 25Tests
EUR 229.2

Anti-CD28 Antibody [CD28.2], PE-Cy7-100Tests

QAB37-PE7-100Tests 100Tests
EUR 340.8

Anti-CD3/CD28 stimulus for human PBMC

CT372 50 tests
EUR 141.6

Anti-CD19/CD22 Bispecific CAR Lentivirus (Clones FMC63/m971 ScFv-CD8-4-1BB-CD3ζ)

78609 50 µl
EUR 1095
Description: The anti-CD19/CD22 Bispecific CAR lentiviruses are replication incompetent, HIV-based, VSV-G-pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. These viruses transduce the ScFv (single-chain variable fragments) of anti-CD19 (clone FMC63) and anti-CD22 (clone m971) linked to a 2nd generation CAR (Chimeric Antigen Receptor) containing CD8 hinge and transmembrane domains, and the 4-1BB and CD3ζ signaling domains.

CAR negative control: CD28-CD3ζ (Puro)

CAR-ctr3 1x10^8 IFU/ml x 200ul
EUR 276.5
Description: CAR-T CD28 control lentivirus without targeting domain, containing Puromycin selection

Anti-BCMA-ScFv- CD28-CD3ζ (Puro) Lentivirus

LVP1651 1x10^8 IFU/ml x 200ul
EUR 553
Description: Anti-BCMA CAR Lentivirus with human CD28 stimulatory domain, containing Puromycin antibiotic selection.

Anti-CD28

E40YR1618 1 mg
EUR 2960
Description: Available in various conjugation types.

anti-CD28

YF-PA10780 50 ug
EUR 435.6
Description: Mouse polyclonal to CD28

Hamster Anti CD28 Antibody

20-abx137056
  • Ask for price
  • Ask for price
  • 0.5 mg
  • 1 mg

Anti-h CD22-ScFv- CD28-CD3ζ (Puro) Lentivirus

LVP1663 1x10^8 IFU/ml x 200ul
EUR 553
Description: Anti-h CD22 CAR Lentivirus with human CD28 stimulatory domain, containing Puromycin antibiotic selection.

Absolute Mcell™ Anti-CD3/CD28 Antibody Magnetic Particles, 5.5 µm, DMF Filed, Sterile

WHM-AB23-095 2.5 mg
EUR 850

Anti-h HER2-ScFv- CD28-CD3ζ (Puro) Lentivirus

LVP1657 1x10^8 IFU/ml x 200ul
EUR 553
Description: Anti-h HER2 CAR Lentivirus with human CD28 stimulatory domain, containing Puromycin antibiotic selection.

Anti-h TGFb-ScFv- CD28-CD3ζ (Puro) Lentivirus

LVP1675 1x10^8 IFU/ml x 200ul
EUR 553
Description: Anti-h TGFb CAR Lentivirus with human CD28 stimulatory domain, containing Puromycin antibiotic selection.

Hamster Anti CD28 FITC Antibody

20-abx137135
  • Ask for price
  • Ask for price
  • 0.5 mg
  • 1 mg

Anti-BCMA-ScFv- CD28-CD3ζ (No Select) Lentivirus

LVP1650 1x10^8 IFU/ml x 200ul
EUR 553
Description: Anti-BCMA CAR Lentivirus with human CD28 stimulatory domain, does not contain any antibiotic selection.

Anti-BCMA-ScFv- CD28-CD3ζ (GFP-Puro) Lentivirus

LVP1652 1x10^8 IFU/ml x 200ul
EUR 553
Description: Anti-BCMA CAR Lentivirus with human CD28 stimulatory domain, containing GFP-Puromycin dual selection.

Anti-CD28 Antibody

E38A8582 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Anti-CD28 Antibody

E38A8787 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Anti-CD28 Antibody

ER2001-42 100ul
EUR 189
Description: CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. T cell stimulation through CD28 in addition to the T-cell receptor (TCR) can provide a potent signal for the production of various interleukins (IL-6 in particular). CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins. When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen-presenting cells (APCs). The CD86 expression on antigen-presenting cells is constitutive (expression is independent of environmental factors). CD28 is the only B7 receptor constitutively expressed on naive T cells. Association of the TCR of a naive T cell with MHC:antigen complex without CD28:B7 interaction results in a T cell that is anergic.

Anti-CD28 antibody

STJ16100044 100 µg
EUR 424.8

Anti-CD28 antibody

STJ72503 100 µg
EUR 430.8

Anti-CD28 antibody

STJ119563 100 µl
EUR 332.4
Description: The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Anti-CD28 antibody

STJ96609 200 µl
EUR 236.4
Description: Rabbit polyclonal to CD28.

Anti-CD28 Antibody

A00065 0.1mg
EUR 449
Description: Boster Bio Anti-CD28 Antibody (Catalog # A00065). Tested in ELISA, WB, IHC, IF applications. This antibody reacts with Human.

Anti-CD19 CAR negative control/ NFAT (Luciferase) Reporter Jurkat Cell Line (CD19 SCFV-CD28 transmembrane motif)

79854 2 vials
EUR 1650
Description: Anti-CD19 CAR negative control/NFAT-luciferase reporter Jurkat cell line is a double stable cell line expressing anti-CD19 CAR negative control and NFAT-luciferase reporter. The anti-CD19 CAR negative control consists of anti-CD19 scFv linked to the CD28 transmembrane motif without any intracellular signaling domains. The reporter cell line has been validated for anti- CD19 expression by FACS, while the stimulation by target cells including CD19/CHO recombinant cell line has not activated the luciferase reporter gene in this cell line. The cell line can be used for the negative control of anti-CD19 CAR/Jurkat-NFAT cell line (BPS Bioscience, #79853)._x000D_ _x000D_

Anti-h CD22-ScFv- CD28-CD3ζ (No Select) Lentivirus

LVP1662 1x10^8 IFU/ml x 200ul
EUR 553
Description: Anti-h CD22 CAR Lentivirus with human CD28 stimulatory domain, does not contain any antibiotic selection.

Anti-h CD22-ScFv- CD28-CD3ζ (GFP-Puro) Lentivirus

LVP1664 1x10^8 IFU/ml x 200ul
EUR 553
Description: Anti-h CD22 CAR Lentivirus with human CD28 stimulatory domain, containing GFP-Puromycin dual selection.

Hamster Anti CD28 Biotinylated Antibody

20-abx137134
  • Ask for price
  • Ask for price
  • 0.5 mg
  • 1 mg

Anti-h HLA-A2-ScFv- CD28-CD3ζ (Puro) Lentivirus

LVP1669 1x10^8 IFU/ml x 200ul
EUR 553
Description: Anti-h HLA-A2 CAR Lentivirus with human CD28 stimulatory domain, containing Puromycin antibiotic selection.

Anti-h HER2-ScFv- CD28-CD3ζ (No Select) Lentivirus

LVP1656 1x10^8 IFU/ml x 200ul
EUR 553
Description: Anti-h HER2 CAR Lentivirus with human CD28 stimulatory domain, does not contain any antibiotic selection.

Anti-h TGFb-ScFv- CD28-CD3ζ (No Select) Lentivirus

LVP1674 1x10^8 IFU/ml x 200ul
EUR 553
Description: Anti-h TGFb CAR Lentivirus with human CD28 stimulatory domain, does not contain any antibiotic selection.

Anti-h HER2-ScFv- CD28-CD3ζ (GFP-Puro) Lentivirus

LVP1658 1x10^8 IFU/ml x 200ul
EUR 553
Description: Anti-h HER2 CAR Lentivirus with human CD28 stimulatory domain, containing GFP-Puromycin dual selection.

Anti-h TGFb-ScFv- CD28-CD3ζ (GFP-Puro) Lentivirus

LVP1676 1x10^8 IFU/ml x 200ul
EUR 553
Description: Anti-h TGFb CAR Lentivirus with human CD28 stimulatory domain, containing GFP-Puromycin dual selection.

Goat Anti-CD28 Antibody

TA311351 100 µg Ask for price

Goat Anti-Cd28 Antibody

TA311383 100 µg Ask for price

Goat anti-CD28 Antibody

dAP-2339 50ug
EUR 264.6

Mouse anti-CD28 Antibody

DL99412A-100ul 100 ul
EUR 299
Description: T-cell-specific surface glycoprotein CD28; TP44; CD28

Mouse anti-CD28 Antibody

DL99412A-50ul 50 ul
EUR 210
Description: T-cell-specific surface glycoprotein CD28; TP44; CD28

Anti-Cd28 (mouse) antibody

STJ72504 100 µg
EUR 430.8

Anti-CD28 Agonist Antibody

100182-1 50 µg
EUR 335
Description: Recombinant monoclonal antibody recognizing human CD28. This antibody binds to CD28 on T cells and promotes T cell response. Not tested in other species. This antibody crosslinked with FcGR2B is useful for activation of CD27 costimulatory pathway in T cells.

Anti-CD28 Agonist Antibody

100182-2 100 µg
EUR 460
Description: Recombinant monoclonal antibody recognizing human CD28. This antibody binds to CD28 on T cells and promotes T cell response. Not tested in other species.

CAR negative control: CD28-CD3ζ (No Select) Lentivirus

CAR-ctr6 1x10^8 IFU/ml x 200ul
EUR 276.5
Description: CAR (CD28) control lentivirus without targeting domain, does not contain any antibiotic selection

CAR negative control: CD28-CD3ζ (GFP-Puro) Lentivirus

CAR-ctr8 1x10^8 IFU/ml x 200ul
EUR 276.5
Description: CAR (CD28) control lentivirus without targeting domain, containing GFP-Puromycin dual selection

Goat anti-Cd28 (mouse) Antibody

dAP-2313 50ug
EUR 264.6

Anti-CD28 Antibody Picoband™

A00065-3 10ug
EUR 154
Description: Western blot, 0.25-0.5 μg/ml, Human;_x000D_Flow Cytometry, 1-3 μg/1x106 cells, Human;_x000D_Direct ELISA, 0.1-0.5 μg/ml, Human

Anti-h HLA-A2-ScFv- CD28-CD3ζ (No Select) Lentivirus

LVP1668 1x10^8 IFU/ml x 200ul
EUR 553
Description: Anti-h HLA-A2 CAR Lentivirus with human CD28 stimulatory domain, does not contain any antibiotic selection.

Rabbit anti-CD28 (pY218) Antibody

DL90184A-100ul 100 ul
EUR 299
Description: T-cell-specific surface glycoprotein CD28; TP44; CD28

Rabbit anti-CD28 (pY218) Antibody

DL90184A-50ul 50 ul
EUR 209.3
Description: T-cell-specific surface glycoprotein CD28; TP44; CD28

Rabbit anti-CD28 (pY218) Antibody

YLD1497-100ul 100 ul
EUR 320
Description: Rabbit polyclonal antibody to CD28 (pY218)

Rabbit anti-CD28 (pY218) Antibody

YLD1497-50ul 50 ul
EUR 200
Description: Rabbit polyclonal antibody to CD28 (pY218)

Anti-h HLA-A2-ScFv- CD28-CD3ζ (GFP-Puro) Lentivirus

LVP1670 1x10^8 IFU/ml x 200ul
EUR 553
Description: Anti-h HLA-A2 CAR Lentivirus with human CD28 stimulatory domain, containing GFP-Puromycin dual selection.

Syrian Hamster anti-CD28 Antibody

DL99429A-100ul 100 ul
EUR 299
Description: T-cell-specific surface glycoprotein CD28; TP44; CD28

Syrian Hamster anti-CD28 Antibody

DL99429A-50ul 50 ul
EUR 210
Description: T-cell-specific surface glycoprotein CD28; TP44; CD28

Anti-CD30 / TNFRSF8 Antibody (CD30/412)

A1484-100 each
EUR 574.8

Anti-CD28 Reference Antibody (FR104)

E24CHA679 100 μg
EUR 225
Description: Available in various conjugation types.

Anti-CD28 Agonist Antibody (Humanized)

100186-1 50 µg
EUR 345
Description: Recombinant monoclonal antibody recognizing human CD28. This antibody binds to CD28 on T cells and promotes T cell response. Not tested in other species. This antibody crosslinked with FcGR2B is useful for activation of CD27 costimulatory pathway in T cells. This antibody has been humanized to reduce immunogenicity and improve the therapeutic half-life.

Anti-CD28 Agonist Antibody (Humanized)

100186-2 100 µg
EUR 475
Description: Recombinant monoclonal antibody recognizing human CD28. This antibody binds to CD28 on T cells and promotes T cell response. Not tested in other species. This antibody has been humanized to reduce immunogenicity and improve the therapeutic half-life.

Anti-CD16/CD32 Antibody

E38A8954 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Anti-CD40/Cd40 Antibody

A00068-1 100ug/vial
EUR 352.8

Anti-CD16+CD32 antibody

MO16A(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16A(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16B(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16B(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16CFB(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16CFB(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16F(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16F(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16F(V500) 500 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PE(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PE(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PP(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PP(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PP5.5(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PP5.5(V25) 25 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PU(V100) 100 ug
EUR 60

Anti-CD16+CD32 antibody

MO16PU(V500) 500 ug
EUR 60

Anti-CD70/Cd27L Antibody

A02853 100ul
EUR 476.4
Description: Rabbit Polyclonal CD70/Cd27L Antibody. Validated in WB and tested in Human.

Rat anti-CD16/CD32 Antibody

DL99452A-100ul 100 ul
EUR 299
Description: CD32; FCG2; IGFR2; Low affinity immunoglobulin gamma Fc region receptor II-b; IgG Fc receptor II-b; CDw32; Fc-gamma RII-b; Fc-gamma-RIIb; FcRII-b; CD32

Rat anti-CD16/CD32 Antibody

DL99452A-50ul 50 ul
EUR 210
Description: CD32; FCG2; IGFR2; Low affinity immunoglobulin gamma Fc region receptor II-b; IgG Fc receptor II-b; CDw32; Fc-gamma RII-b; Fc-gamma-RIIb; FcRII-b; CD32

Anti-CD59/Cd59a Antibody

A00914 100ug/vial
EUR 400.8

Anti-CD22 CAR Lentivirus (Clone m971 ScFv-CD8-4-1BB-CD3ζ)

78608 50 µl
EUR 1095
Description: The anti-CD22 CAR lentiviruses are replication incompetent, HIV-based, VSV-G-pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. These viruses transduce the ScFv (single-chain variable fragment) of anti-CD22 (clone m971) linked to a 2nd generation CAR (Chimeric Antigen Receptor) containing CD8 hinge and transmembrane domains, and the 4-1BB and CD3ζ signaling domains (below).

Anti-CD40L/CD40LG Antibody

A01114-1 100ug/vial
EUR 352.8

Anti-CD40L/Cd40lg Antibody

A01114-2 100ug/vial
EUR 400.8

Anti-CD40L/CD40LG Antibody

A01114-3 100ug/vial
EUR 352.8

Anti-CD16/CD32, Rat IgG2b Antibody

A1106-200 each
EUR 874.8

Recombinant Anti-CD33 x Anti-CD16 x CD123 Trispecific Antibody (Single-chain Triplebody)

SCTB-104 200μg Ask for price
Description: A trispecific antibody that is expressed as a single chain with three scFv units, two distal binding sites for CD33 and CD123, a central site for CD16. This BsAb can retarget NK cells to tumor cells. It is designed for the research of Acute myeloid leukemia (AML) therapy.

Anti-EMMPRIN / CD147 Reference Antibody (Centocor anti-CD147)

E24CHA651 100 μg
EUR 225
Description: Available in various conjugation types.

Anti-OX2R / CD200R1 Reference Antibody (Janssen anti-CD200R1)

E24CHA149 100 μg
EUR 225
Description: Available in various conjugation types.

Anti-CD16/CD32, Rabbit IgG Antibody

A1107-200 each
EUR 874.8

Anti-CD28 (lumretuzumab)-MC-MMAF ADC

ADC-W-2278 1mg Ask for price
Description: This ADC product is comprised of an anti-CD28 monoclonal antibody conjugated via a MC linker to MMAF

Anti-CD28 (lumretuzumab)-SMCC-DM1 ADC

ADC-W-2276 1mg Ask for price
Description: This ADC product is comprised of an anti-CD28 monoclonal antibody conjugated via a SMCC linker to DM1

Anti-CD28 (lumretuzumab)-SPDB-DM4 ADC

ADC-W-2277 1mg Ask for price
Description: This ADC product is comprised of an anti-CD28 monoclonal antibody conjugated via a SPDB linker to DM4

Anti-CD3-ZETA / CD247 antibody

STJ73100 100 µg
EUR 430.8

Anti-CD44v4 Antibody (Clone CD44v4/1219)

A1526-100 each
EUR 574.8

Anti-CD44v6 Antibody (Clone CD44v6/1246)

A1527-100 each
EUR 574.8

Anti-CD44v9 Antibody (Clone CD44v9/1459)

A1528-100 each
EUR 574.8

Anti-CD20 CAR Lentivirus (Clone Leu-16 ScFv-CD8-4-1BB-CD3ζ)

78606 50 µl
EUR 1095
Description: The anti-CD20 CAR lentiviruses are replication incompetent, HIV-based, VSV-G-pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. These viruses transduce the ScFv (single-chain variable fragment) of anti-CD20 (clone Leu-16) linked to a 2nd generation CAR (Chimeric Antigen Receptor) containing CD8 hinge and transmembrane domains, and the 4-1BB and CD3ζ signaling domains .

Anti-CD28 Antibody [37.51], Unconjugated-25ug

QAB99-25ug 25ug
EUR 138

Anti-CD28 Antibody [37.51], Unconjugated-100ug

QAB99-100ug 100ug
EUR 178.8

Anti-CD28 Antibody [37.51], Unconjugated-500ug

QAB99-500ug 500ug
EUR 279.6

Goat anti-CD3-ZETA / CD247 Antibody

dAP-3199 50ug
EUR 264.6

Anti-CD28 Antibody [37.51], Qfluor 630-100ug

QAB99-QF630-100ug 100ug
EUR 270

Anti-CD28 Antibody [37.51], Qfluor 630-500ug

QAB99-QF630-500ug 500ug
EUR 372

Anti-CD28 (lulizumab pegol)-MC-MMAF ADC

ADC-W-2332 1mg Ask for price
Description: This ADC product is comprised of an anti-CD28 Monovalent antibody conjugated via a MC linker to MMAF

resDetect™ Anti-CD28 Antibody ELISA Kit

CRS-A014 96tests
EUR 652.7
Description: Similar to CD3 antibody, CD28 antibodies also can be used to stimulate the proliferation and activation of T cells in CIK cell therapy. Under the cooperation of other cytokines, such as IL2 and IL1a, CIK cells with rapid proliferation, high tumoricidal activity, broad tumor killing spectrum and non-MHC-restricted tumor killing characteristics are generated,which has significant effects on the treatment of cancer, chronic leukemia, liver disease and neurological diseases. Obviously, It is necessary to control the residues of raw materials in the final cell therapy products.

Anti-CD30/ TNFRSF8 Antibody Clone CD30/412, Unconjugated-20ug

943-MSM1-P0 20ug
EUR 279.6

Anti-CD28 (lulizumab pegol)-SMCC-DM1 ADC

ADC-W-2330 1mg Ask for price
Description: This ADC product is comprised of an anti-CD28 Monovalent antibody conjugated via a SMCC linker to DM1

Anti-CD28 (lulizumab pegol)-SPDB-DM4 ADC

ADC-W-2331 1mg Ask for price
Description: This ADC product is comprised of an anti-CD28 Monovalent antibody conjugated via a SPDB linker to DM4

The RNA Modification Database is staying up-to-date with important enhancements being ready for inclusion throughout the subsequent 12 months and the next 12 months. The expanded future position of The RNA Modification Database shall be to function a major info portal for researchers throughout the whole spectrum of RNA-related analysis. Most not too long ago, partly pushed by NIH roadmap initiatives, issues have arisen as to what tool-like means within the seek for chemical instruments to probe biology house.