Peptides

The CERHR Expert Panel on Bisphenol A accomplished its analysis in August 2007.

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ASH sensory neurons are required in Caenorhabditis elegans for a wide range of avoidance behaviors in response to chemical repellents, high osmotic solutions and nose touch. The ASH neurons are therefore hypothesized to be polymodal nociceptive neurons. To understand the nature of polymodal sensory response and adaptation at the cellular level, we expressed the calcium indicator protein cameleon in ASH and analyzed intracellular Ca(2+) responses following stimulation with chemical repellents, osmotic shock and nose touch. We found that a variety of noxious stimuli evoked strong responses in ASH including quinine, denatonium, detergents, heavy metals, both hyper- and hypo-osmotic shock and nose touch. We observed that repeated chemical stimulation led to a reversible reduction in the magnitude of the sensory response, indicating that adaptation occurs within the ASH sensory neuron. A key component of ASH adaptation is GPC-1, a G-protein gamma-subunit expressed specifically in chemosensory neurons. We hypothesize that G-protein gamma-subunit heterogeneity provides a mechanism for repellent-specific adaptation, which could facilitate discrimination of a variety of repellents by these polymodal sensory neurons.

The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) carried out an analysis of the potential for bisphenol A to trigger opposed results on copy and growth in people. The CERHR Expert Panel on Bisphenol A accomplished its analysis in August 2007. CERHR chosen bisphenol A for analysis as a result of of the: widespread human publicity; public concern for doable well being results from human exposures; high manufacturing quantity; proof of reproductive and developmental toxicity in laboratory animal research Bisphenol A (CAS RN: 80-05-7) is a high manufacturing quantity chemical used primarily in the manufacturing of polycarbonate plastics and epoxy resins.

Polycarbonate plastics are used in some meals and drink containers; the resins are used as lacquers to coat steel merchandise similar to meals cans, bottle tops, and water provide pipes. To a lesser extent bisphenol A is used in the manufacturing of polyester resins, polysulfone resins, polyacrylate resins, and flame retardants. In addition, bisphenol A is used in the processing of polyvinyl chloride plastic and in the recycling of thermal paper. Some polymers used in dental sealants and tooth coatings comprise bisphenol A. The major supply of publicity to bisphenol A for most individuals is assumed to happen via the food regimen.

While air, mud, and water (including pores and skin contact throughout bathing and swimming) are different doable sources of publicity, bisphenol A in meals and drinks accounts for the majority of each day human publicity. The highest estimated each day intakes of bisphenol A in the common inhabitants happen in infants and youngsters. The outcomes of this bisphenol A analysis are printed in an NTP-CERHR Monograph that consists of the (1) NTP Brief and (2) Expert Panel Report on the Reproductive and Developmental Toxicity of Bisphenol A. Additional info associated to the analysis course of, including the peer overview report for the NTP Brief and public feedback acquired on the draft NTP Brief and the closing knowledgeable panel report.

See bisphenol A below “CERHR Chemicals” on the homepage. The NTP reached the following conclusions on the doable results of publicity to bisphenol A on human growth and copy. Note that the doable ranges of concern, from lowest to highest, are negligible concern, minimal concern, some concern, concern, and critical concern. The NTP has some concern for results on the mind, habits, and prostate gland in fetuses, infants, and youngsters at present human exposures to bisphenol A. The NTP has minimal concern for results on the mammary gland and an earlier age for puberty for females in fetuses, infants, and youngsters at present human exposures to bisphenol A.

The NTP has negligible concern that publicity of pregnant girls to bisphenol A will outcome in fetal or neonatal mortality, beginning defects, or lowered beginning weight and development in their offspring. The NTP has negligible concern that publicity to bisphenol A will trigger reproductive results in non-occupationally uncovered adults and minimal concern for staff uncovered to larger ranges in occupational settings.

Myocardial calcium and magnesium in acute ischemic damage.

The impact of ischemic damage on calcium and magnesium distribution in canine myocardial cells was investigated in tissue broken by occlusion of the circumflex department of the left coronary artery for 60 minutes or for 40 minutes adopted by 20 minutes of reperfusion of the broken tissue by arterial blood. No vital change in the focus of these cations was famous in completely ischemic, irreversibly injured myocardial cells, however tissue calcium was markedly elevated in cells killed by an episode of transient ischemia. Tissue water and sodium additionally have been elevated and magnesium was decreased considerably in the transient ischemia mannequin.

Investigation of the localization of the elevated Ca(–) by cellular fractionation and chemical evaluation in addition to by electron miscroscopy and microincineration confirmed that a lot of it was localized in dense our bodies within the mitochondria. Within the intramitochondrial dense our bodies, the calcium appeared to be a precipitate of an as but undefined kind of calcium phosphate. Dormant Bacillus subtilis spores can be induced to germinate by vitamins, in addition to by nonmetabolizable chemical compounds, similar to a 1:1 chelate of Ca(2+) and dipicolinic acid (DPA).

Nutrients bind receptors in the spore, and this binding triggers occasions in the spore core, including DPA excretion and rehydration, and additionally prompts hydrolysis of the surrounding cortex via mechanisms that are largely unknown. As Ca(2+)-DPA doesn’t require receptors to induce spore germination, we requested if this course of makes use of different proteins, similar to the putative cortex-lytic enzymes SleB and CwlJ, that are concerned in nutrient-induced germination.

ASH sensory neurons are required in Caenorhabditis elegans for a wide range of avoidance behaviors in response to chemical repellents, high osmotic solutions and nose touch. The ASH neurons are therefore hypothesized to be polymodal nociceptive neurons. To understand the nature of polymodal sensory response and adaptation at the cellular level, we expressed the calcium indicator protein cameleon in ASH and analyzed intracellular Ca(2+) responses following stimulation with chemical repellents, osmotic shock and nose touch. We found that a variety of noxious stimuli evoked strong responses in ASH including quinine, denatonium, detergents, heavy metals, both hyper- and hypo-osmotic shock and nose touch. We observed that repeated chemical stimulation led to a reversible reduction in the magnitude of the sensory response, indicating that adaptation occurs within the ASH sensory neuron. A key component of ASH adaptation is GPC-1, a G-protein gamma-subunit expressed specifically in chemosensory neurons. We hypothesize that G-protein gamma-subunit heterogeneity provides a mechanism for repellent-specific adaptation, which could facilitate discrimination of a variety of repellents by these polymodal sensory neurons.

The transient receptor potential channel TRPA1: from gene to pathophysiology.

The Transient Receptor Potential Ankyrin 1 channel (TRPA1), is a member of the massive TRP household of ion channels, and features as a Ca(2+) permeable non-selective cation channel in many alternative cell processes, starting from sensory to homeostatic duties. TRPA1 is extremely conserved throughout the animal kingdom. The solely mammalian TRPA subfamily member, TRPA1, is extensively expressed in neuronal (e.g. sensory dorsal root and trigeminal ganglia neurons)- and in non-neuronal cells (e.g. epithelial cells, hair cells). It reveals 14-19 amino-(N-)terminal ankyrin repeats, an uncommon structural function.

Caspase-8 Fluorometric Assay Kit
K2012-25 25 assays
EUR 238

Caspase-2 Fluorometric Assay Kit
K2016-25 25 assays
EUR 238

Caspase-9 Fluorometric Assay Kit
K2018-25 25 assays
EUR 238

Caspase-12 Fluorometric Assay Kit
K2150-25 25 assays
EUR 251

Caspase-5 Fluorometric Assay Kit
K2195-25 25 assays
EUR 238

Caspase-4 Fluorometric Assay Kit
K2198-25 25 assays
EUR 251

Caspase-3 Fluorometric Assay Kit
K105-25
EUR 207

Caspase-1 Fluorometric Assay Kit
K110-25
EUR 207

Caspase-8 Fluorometric Assay Kit
K112-25
EUR 207

Caspase-2 Fluorometric Assay Kit
K116-25
EUR 202

Caspase-9 Fluorometric Assay Kit
K118-25
EUR 207

Caspase-5 Fluorometric Assay Kit
K122-25
EUR 202

Caspase-10 Fluorometric Assay Kit
K124-25
EUR 202

Caspase-4 Fluorometric Assay Kit
K126-25
EUR 213

Caspase-12 Fluorometric Assay Kit
K139-25
EUR 256

Caspase-8 IETD-R110 Fluorometric and Colorimetric Assay Kit (25 assays)
30011-1 1KIT
EUR 204
Description: Minimum order quantity: 1 unit of 1KIT

Caspase-6 Fluorometric Assay Kit
K2014-200 200 assays
EUR 696

Caspase-6 Fluorometric Assay Kit
K2014-400 400 assays
EUR 1086

Caspase-6 Fluorometric Assay Kit
K114-100
EUR 430

Caspase-6 Fluorometric Assay Kit
K114-200
EUR 615

Caspase-6 Fluorometric Assay Kit
K114-400
EUR 958

Caspase 6 Fluorometric Assay Kit
55R-1276 25 assays
EUR 287
Description: Assay Kit for detection of Capase 6 activity in the research laboratory

Caspase-6 Colorimetric Assay Kit
K2015-25 25 assays
EUR 238

Caspase-6 Colorimetric Assay Kit
K115-25
EUR 202

CASPASE3 DEVDR110 ASSAY (25 ASSAYS)
30008-1 1KIT
EUR 204
Description: Minimum order quantity: 1 unit of 1KIT

Caspase-3 DEVD-R110 Fluorometric and Colorimetric Assay Kit (100 assays)
30008-2 1KIT
EUR 383
Description: Minimum order quantity: 1 unit of 1KIT

Caspase-8 IETD-R110 Fluorometric and Colorimetric Assay Kit (100 assays)
30011-2 1KIT
EUR 383
Description: Minimum order quantity: 1 unit of 1KIT

Caspase-3 Fluorometric Assay Kit
K2007-200 200 assays
EUR 696

Caspase-3 Fluorometric Assay Kit
K2007-400 400 assays
EUR 1086

Caspase-1 Fluorometric Assay Kit
K2010-200 200 assays
EUR 696

Caspase-1 Fluorometric Assay Kit
K2010-400 400 assays
EUR 1086

Caspase-8 Fluorometric Assay Kit
K2012-200 200 assays
EUR 696

Caspase-8 Fluorometric Assay Kit
K2012-400 400 assays
EUR 1086

Caspase-2 Fluorometric Assay Kit
K2016-200 200 assays
EUR 696

Caspase-2 Fluorometric Assay Kit
K2016-400 400 assays
EUR 1114

Caspase-9 Fluorometric Assay Kit
K2018-200 200 assays
EUR 669

Caspase-9 Fluorometric Assay Kit
K2018-400 400 assays
EUR 1114

Caspase-12 Fluorometric Assay Kit
K2150-100 100 assays
EUR 529

Caspase-5 Fluorometric Assay Kit
K2195-100 100 assays
EUR 502

Caspase-5 Fluorometric Assay Kit
K2195-200 200 assays
EUR 696

Caspase-5 Fluorometric Assay Kit
K2195-400 400 assays
EUR 1114

Caspase-4 Fluorometric Assay Kit
K2198-100 100 assays
EUR 529

Caspase-4 Fluorometric Assay Kit
K2198-200 200 assays
EUR 738

Caspase-4 Fluorometric Assay Kit
K2198-400 400 assays
EUR 1114

Caspase-3 Fluorometric Assay Kit
K105-100
EUR 479

Caspase-3 Fluorometric Assay Kit
K105-200
EUR 620

Caspase-3 Fluorometric Assay Kit
K105-400
EUR 979

Caspase-1 Fluorometric Assay Kit
K110-100
EUR 479

Caspase-1 Fluorometric Assay Kit
K110-200
EUR 620

Caspase-1 Fluorometric Assay Kit
K110-400
EUR 958

Caspase-8 Fluorometric Assay Kit
K112-100
EUR 479

Caspase-8 Fluorometric Assay Kit
K112-200
EUR 615

Caspase-8 Fluorometric Assay Kit
K112-400
EUR 958

Caspase-2 Fluorometric Assay Kit
K116-100
EUR 463

Caspase-2 Fluorometric Assay Kit
K116-200
EUR 615

Caspase-2 Fluorometric Assay Kit
K116-400
EUR 958

Caspase-9 Fluorometric Assay Kit
K118-100
EUR 468

Caspase-9 Fluorometric Assay Kit
K118-200
EUR 615

Caspase-9 Fluorometric Assay Kit
K118-400
EUR 958

Caspase-5 Fluorometric Assay Kit
K122-100
EUR 436

Caspase-5 Fluorometric Assay Kit
K122-200
EUR 582

Caspase-5 Fluorometric Assay Kit
K122-400
EUR 958

Caspase-10 Fluorometric Assay Kit
K124-100
EUR 441

Caspase-10 Fluorometric Assay Kit
K124-200
EUR 615

Caspase-10 Fluorometric Assay Kit
K124-400
EUR 958

Caspase-4 Fluorometric Assay Kit
K126-100
EUR 468

Caspase-4 Fluorometric Assay Kit
K126-200
EUR 615

Caspase-4 Fluorometric Assay Kit
K126-400
EUR 925

Caspase-12 Fluorometric Assay Kit
K139-100
EUR 501

Caspase 3 Fluorometric Assay Kit
55R-1269 25 assays
EUR 277
Description: Assay Kit for detection of Capase 3 activity in the research laboratory

Caspase 1 Fluorometric Assay Kit
55R-1272 25 assays
EUR 277
Description: Assay Kit for detection of Capase 1 activity in the research laboratory

Caspase 8 Fluorometric Assay Kit
55R-1274 25 assays
EUR 277
Description: Assay Kit for detection of Capase 8 activity in the research laboratory

Caspase 2 Fluorometric Assay Kit
55R-1278 25 assays
EUR 284
Description: Assay Kit for detection of Capase 2 activity in the research laboratory

Caspase 9 Fluorometric Assay Kit
55R-1280 25 assays
EUR 277
Description: Assay Kit for detection of Capase 9 activity in the research laboratory

Caspase 5 Fluorometric Assay Kit
55R-1282 25 assays
EUR 284
Description: Assay Kit for detection of Capase 5 activity in the research laboratory

Caspase 10 Fluorometric Assay Kit
55R-1284 25 assays
EUR 284
Description: Assay Kit for detection of Capase 10 activity in the research laboratory

Caspase 4 Fluorometric Assay Kit
55R-1286 25 assays
EUR 303
Description: Assay Kit for detection of Capase 4 activity in the research laboratory

Caspase 6 Assay Kit
20-abx299018
  • EUR 1302.00
  • EUR 582.00
  • 100 tests
  • 25 tests

Caspase-3 Activity Assay Kit II (Fluorometric)
K533-100
EUR 512

Glucose-6-Phosphate Fluorometric Assay Kit
K2220-100 100 assays
EUR 599

Fructose-6-Phosphate Fluorometric Assay Kit
K2222-100 100 assays
EUR 599

Caspase Fluorometric Substrate Set
K131-7-25
EUR 544

Caspase-3 Colorimetric Assay Kit
K2008-25 25 assays
EUR 238

Caspase-1 Colorimetric Assay Kit
K2011-25 25 assays
EUR 238

Caspase-8 Colorimetric Assay Kit
K2013-25 25 assays
EUR 238

Caspase-2 Colorimetric Assay Kit
K2017-25 25 assays
EUR 251

Caspase-9 Colorimetric Assay Kit
K2019-25 25 assays
EUR 251

Caspase-5 Colorimetric Assay Kit
K2196-25 25 assays
EUR 251

Caspase-10 Colorimetric Assay Kit
K2197-25 25 assays
EUR 251

Caspase-4 Colorimetric Assay Kit
K2199-25 25 assays
EUR 266

Caspase-3 Colorimetric Assay Kit
K106-25
EUR 207

Caspase-1 Colorimetric Assay Kit
K111-25
EUR 207

Caspase-8 Colorimetric Assay Kit
K113-25
EUR 207

Caspase-2 Colorimetric Assay Kit
K117-25
EUR 213

Caspase-9 Colorimetric Assay Kit
K119-25
EUR 218

Caspase-5 Colorimetric Assay Kit
K123-25
EUR 213

The TRPA1 channel is activated by noxious chilly (<17 °C) in addition to by a plethora of chemical compounds that consists of not solely electrophilic compounds and oxidants that can modify, in an alkylative or oxidative vogue, nucleophilic cysteine residues in the channel’s N-terminus, but in addition compounds that don’t covalently bind to the channel proteins (e.g. menthol, nifedipin). Based on localization and purposeful properties, TRPA1 is thought-about a key participant in acute and power (neuropathic) ache and irritation. Moreover, its position in the (patho)physiology of practically all organ methods is anticipated, and will be mentioned alongside with the potential of TRPA1 as a drug goal for the administration of numerous pathological circumstances.

Using chemical shift perturbation to characterise ligand binding.

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Using chemical shift perturbation to characterise ligand binding.

Chemical shift perturbation (CSP, chemical shift mapping or complexation-induced modifications in chemical shift, CIS) follows modifications within the chemical shifts of a protein when a ligand is added, and makes use of these to decide the placement of the binding web site, the affinity of the ligand, and/or presumably the construction of the advanced. A key consider figuring out the looks of spectra throughout a titration is the change price between free and certain, or extra particularly the off-rate koff. When koff is bigger than the chemical shift distinction between free and certain, which generally equates to an affinity Kd weaker than about 3μM, then change is quick on the chemical shift timescale.

Under these circumstances, the noticed shift is the population-weighted common of free and certain, which permits Kd to be decided from measurement of peak positions, offered the measurements are made appropriately. (1)H shifts are influenced to a big extent by through-space interactions, whereas (13)Cα and (13)Cβ shifts are influenced extra by through-bond results. (15)N and (13)C’ shifts are influenced each by through-bond and by through-space (hydrogen bonding) interactions. For figuring out the placement of a certain ligand on the idea of shift change, probably the most acceptable methodology is subsequently normally to measure (15)N HSQC spectra, calculate the geometrical distance moved by the height, weighting (15)N shifts by an element of about 0.14 in contrast to (1)H shifts, and choose these residues for which the weighted shift change is bigger than the usual deviation of the shift for all residues.

Other strategies are mentioned, particularly the measurement of (13)CH3 indicators. Slow to intermediate change charges lead to line broadening, and make Kd values very troublesome to acquire. There isn’t any great way to distinguish modifications in chemical shift due to direct binding of the ligand from modifications in chemical shift due to allosteric change. Ligand binding at a number of websites can typically be characterised, by simultaneous becoming of many measured shift modifications, or extra just by including substoichiometric quantities of ligand. The chemical shift modifications can be utilized as restraints for docking ligand onto protein. By use of quantitative calculations of ligand-induced chemical shift modifications, it’s changing into potential to decide not simply the place but in addition the orientation of ligands.

Glutamate and neurotrophic elements in neuronal plasticity and illness.

Glutamate’s position as a neurotransmitter at synapses has been recognized for 40 years, however glutamate has since been proven to regulate neurogenesis, neurite outgrowth, synaptogenesis, and neuron survival within the creating and grownup mammalian nervous system. Cell-surface glutamate receptors are coupled to Ca(2+) inflow and launch from endoplasmic reticulum shops, which causes speedy (kinase- and protease-mediated) and delayed (transcription-dependent) responses that change the construction and performance of neurons. Neurotrophic elements and glutamate work together to regulate developmental and grownup neuroplasticity. For instance, glutamate stimulates the manufacturing of brain-derived neurotrophic issue (BDNF), which, in flip, modifies neuronal glutamate sensitivity, Ca(2+) homeostasis, and plasticity.

Neurotrophic elements could modify glutamate signaling straight, by altering the expression of glutamate receptor subunits and Ca(2+)-regulating proteins, and likewise not directly by inducing the manufacturing of antioxidant enzymes, energy-regulating proteins, and antiapoptotic Bcl-2 relations. Excessive activation of glutamate receptors, beneath situations of oxidative and metabolic stress, could contribute to neuronal dysfunction and degeneration in ailments starting from stroke and Alzheimer’s illness to psychiatric issues. By enhancing neurotrophic issue signaling, environmental elements comparable to train and dietary vitality restriction, and chemical compounds comparable to antidepressants could optimize glutamatergic signaling and shield in opposition to neurological issues.

Using chemical shift perturbation to characterise ligand binding.

Glial cells in (patho)physiology.

Neuroglial cells outline mind homeostasis and mount protection in opposition to pathological insults. Astroglia regulate neurogenesis and improvement of mind circuits. In the grownup mind, astrocytes enter into intimate dynamic relationship with neurons, particularly at synaptic websites the place they functionally kind the tripartite synapse. At these websites, astrocytes regulate ion and neurotransmitter homeostasis, metabolically help neurons and monitor synaptic exercise; one of many readouts of the latter manifests in astrocytic intracellular Ca(2+) indicators. This type of astrocytic excitability can lead to launch of chemical transmitters by way of Ca(2+) -dependent exocytosis.

Once within the extracellular area, gliotransmitters can modulate synaptic plasticity and trigger modifications in habits. Besides these physiological duties, astrocytes are elementary for development and final result of neurological ailments. In Alzheimer’s illness, for instance, astrocytes could contribute to the etiology of this dysfunction. Highly deadly glial-derived tumors use signaling trickery to coerce regular mind cells to help tumor invasiveness. This evaluation not solely sheds new gentle on the mind operation in well being and illness, but in addition factors to many unknowns.

Caspase 14 p10 antibody
70R-50903 100 ul
EUR 244
Description: Purified Polyclonal Caspase 14 p10 antibody

Anti-Caspase-1(P10)/CASP1 Antibody
PA1522 100ug/vial
EUR 334

Caspase 1 (p10, Cleaved-Ala317) Antibody
20-abx015550
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Cleaved Caspase-1 (Arg317) /P10 Antibody
AF4022 200ul
EUR 376
Description: Caspase 1 (p10,Cleaved-Arg317) Antibody detects endogenous levels of fragment of activated Caspase 1 resulting from cleavage adjacent to Arg317.

Caspase 1 p10 Blocking Peptide
20-abx062325
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Anti-Caspase-3 (P10)/CASP3 Antibody
PA1302 100ug/vial
EUR 294

Anti-Caspase-3 (P10)/CASP3 Antibody
PA1302-2 100ug/vial
EUR 334

Anti-Caspase-8(P10)/CASP8 Antibody
PA1524 100ug/vial
EUR 334

Caspase 14 (p10, Cleaved-Lys222) Antibody
20-abx015552
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Caspase 5 (p10, Cleaved-Ser331) Antibody
20-abx015560
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Caspase 5 p10 Blocking Peptide
20-abx062339
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Caspase 14 p10 Blocking Peptide
20-abx063778
  • EUR 272.00
  • EUR 411.00
  • 1 mg
  • 5 mg

Cleaved Caspase-1 (Arg317) /P10 Blocking Peptide
AF4022-BP 1mg
EUR 195

Cleaved-Caspase-5 p10 (S331) Polyclonal Antibody
ES1020-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Cleaved-Caspase-5 p10 (S331) from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

Cleaved-Caspase-5 p10 (S331) Polyclonal Antibody
ES1020-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Cleaved-Caspase-5 p10 (S331) from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

Cleaved-Caspase-5 p10 (S331) Polyclonal Antibody
ABP50021-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of Cleaved-Caspase-5 p10 S331) from Human. This Cleaved-Caspase-5 p10 S331) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Caspase-5 p10 at AA range: 290-370

Cleaved-Caspase-5 p10 (S331) Polyclonal Antibody
ABP50021-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of Cleaved-Caspase-5 p10 S331) from Human. This Cleaved-Caspase-5 p10 S331) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Caspase-5 p10 at AA range: 290-370

Cleaved-Caspase-5 p10 (S331) Polyclonal Antibody
ABP50021-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of Cleaved-Caspase-5 p10 S331) from Human. This Cleaved-Caspase-5 p10 S331) antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Caspase-5 p10 at AA range: 290-370

Anti-Cleaved-Caspase-5 p10 (S331) antibody
STJ90029 200 µl
EUR 197
Description: Rabbit polyclonal to Cleaved-Caspase-5 p10 (S331).

Cleaved-Caspase-5 p10 (S331) Polyclonal Antibody
40509-100ul 100ul
EUR 252

Cleaved-Caspase-5 p10 (S331) Polyclonal Antibody
40509-50ul 50ul
EUR 187

Anti-Caspase-1(P20)/CASP1 Antibody
PA1440-1 100ug/vial
EUR 294

Anti-Caspase 8/CASP8 Antibody
A00042-1 100ug/vial
EUR 294

Anti-Caspase-2/CASP2 Antibody
A02384-1 100ug/vial
EUR 334

Anti-Caspase 4/CASP4 Antibody
A02941-1 100ug/vial
EUR 334

Anti-Caspase-8 Rabbit Monoclonal Antibody
M00042-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal Caspase-8 Antibody. Validated in IF, WB and tested in Human.

Anti-Caspase-7 Rabbit Monoclonal Antibody
M01044-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal Caspase-7 Antibody. Validated in IP, WB and tested in Mouse, Rat.

Anti-Caspase-10 Rabbit Monoclonal Antibody
M02190-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal Caspase-10 Antibody. Validated in IP, WB and tested in Human.

Anti-Caspase-2 Rabbit Monoclonal Antibody
M02384-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal Caspase-2 Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat.

Anti-Caspase-6(P18)/CASP6 Antibody
PA1441-1 100ug/vial
EUR 334

Anti-Caspase-3(P17)/CASP3 Antibody
PA1961-1 100ug/vial
EUR 334

Caspase-1 Antibody
24290-100ul 100ul
EUR 390

Caspase-1 Antibody
24291-100ul 100ul
EUR 390

caspase 1 Antibody
39310-100ul 100ul
EUR 390

Caspase-1 Antibody
48847-100ul 100ul
EUR 333

Caspase-1 Antibody
48847-50ul 50ul
EUR 239

Caspase 1 Antibody
AF5418 200ul
EUR 304
Description: Caspase 1 Antibody detects endogenous levels of total Caspase 1.

Caspase 1 Antibody
ABF5418 100 ug
EUR 438

Caspase 1 Antibody
6687-100
EUR 338

Caspase 1 Antibody
6687-30T
EUR 146

Caspase-1 Antibody
3019-100
EUR 403

Caspase-1 Antibody
3019-30T
EUR 146

Caspase 1 antibody
PAab10015 100 ug
EUR 386

Caspase 1 antibody
20R-1427 100 ug
EUR 651
Description: Rabbit polyclonal Caspase 1 antibody

Caspase 1 antibody
70R-15367 100 ug
EUR 327
Description: Rabbit polyclonal Caspase 1 antibody

Caspase-1 Antibody
3459-002mg 0.02 mg
EUR 171.82
Description: Caspase-1 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1β and IL-18. Caspase-1 was initially identified as an IL-1β-converting enzyme; later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 whose overexpression can induce apoptosis in fibroblasts.

Caspase-1 Antibody
3459-01mg 0.1 mg
EUR 436.42
Description: Caspase-1 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1β and IL-18. Caspase-1 was initially identified as an IL-1β-converting enzyme; later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 whose overexpression can induce apoptosis in fibroblasts.

Caspase-1 Antibody
3463-002mg 0.02 mg
EUR 171.82
Description: Caspase-1 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1β and IL-18. Caspase-1 was initially identified as an IL-1β-converting enzyme; later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 whose overexpression can induce apoptosis in fibroblasts.

Caspase-1 Antibody
3463-01mg 0.1 mg
EUR 436.42
Description: Caspase-1 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1β and IL-18. Caspase-1 was initially identified as an IL-1β-converting enzyme; later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 whose overexpression can induce apoptosis in fibroblasts.

Caspase 1 antibody
70R-11561 100 ug
EUR 527
Description: Rabbit polyclonal Caspase 1 antibody

Caspase 1 antibody
70R-13979 100 ug
EUR 322
Description: Affinity purified Rabbit polyclonal Caspase 1 antibody

Caspase 1 antibody
70R-14061 100 ug
EUR 322
Description: Affinity purified Rabbit polyclonal Caspase 1 antibody

Caspase 1 antibody
70R-31086 100 ug
EUR 327
Description: Rabbit polyclonal Caspase 1 antibody

Caspase 1 antibody
70R-31087 100 ug
EUR 327
Description: Rabbit polyclonal Caspase 1 antibody

Caspase 1 antibody
70R-31116 100 ug
EUR 327
Description: Rabbit polyclonal Caspase 1 antibody

Caspase 1 antibody
70R-49451 100 ul
EUR 244
Description: Purified Polyclonal Caspase 1 antibody

Caspase 1 antibody
70R-49452 100 ul
EUR 244
Description: Purified Polyclonal Caspase 1 antibody

Caspase 1 antibody
70R-51474 100 ul
EUR 244
Description: Purified Polyclonal Caspase 1 antibody

Caspase 1 antibody
70R-35920 100 ug
EUR 327
Description: Rabbit polyclonal Caspase 1 antibody

3-D Life RGD Peptide
P10-3 3x 1 µmol
EUR 276

Anti-pro Caspase 9 Rabbit Monoclonal Antibody
M00080-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal pro Caspase 9 Antibody. Validated in WB and tested in Human.

Anti-pro Caspase 3 Rabbit Monoclonal Antibody
M00334-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal pro Caspase 3 Antibody. Validated in IP, IF, WB and tested in Human, Mouse.

Anti-Caspase-6 p18 Rabbit Monoclonal Antibody
M02631-1 100ug/vial
EUR 397
Description: Rabbit Monoclonal Caspase-6 p18 Antibody. Validated in IP, WB and tested in Human.

Caspase Inhibitor Set I
A9901-1 1 Set
EUR 154

Caspase-3/7 Inhibitor
2780-1
EUR 153

Caspase-3/7 Inhibitor I
A1925-1 1 mg
EUR 148
Description: Caspase-3/7 inbibitor I is a potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (KI(app) = 60 nM) and caspase-7 (KI(app) = 170 nM). Is a weaker inhibitor of caspase-9 (Ki(app) = 3.1 mM).

Caspase-1 Polyclonal Antibody
ES7677-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Caspase-1 from Human/Monkey. This antibody is tested and validated for WB, ELISA, WB, ELISA

Caspase-1 Polyclonal Antibody
ES7677-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Caspase-1 from Human/Monkey. This antibody is tested and validated for WB, ELISA, WB, ELISA

Caspase-1 Polyclonal Antibody
ES8461-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Caspase-1 from Human/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Caspase-1 Polyclonal Antibody
ES8461-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Caspase-1 from Human/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Caspase 1 (CASP1) Antibody
20-abx301352
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Caspase 1 (pS376) Antibody
abx148922-100ug 100 ug
EUR 439

Caspase-1 Polyclonal Antibody
ES1850-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Caspase-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Caspase-1 Polyclonal Antibody
ES1850-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Caspase-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Anti-Caspase-1 Antibody
A00048 100ug
EUR 432
Description: Rabbit Polyclonal Caspase-1 Antibody. Validated in IP, IF, IHC, WB and tested in Human, Mouse, Rat.

Caspase 1 (CASP1) Antibody
20-abx109605
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Caspase 1 (CASP1) Antibody
20-abx100442
  • EUR 411.00
  • EUR 133.00
  • EUR 1149.00
  • EUR 565.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Caspase 1 (CASP1) Antibody
20-abx100443
  • EUR 411.00
  • EUR 133.00
  • EUR 1149.00
  • EUR 565.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Caspase 1 (CASP1) Antibody
20-abx100444
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Caspase 1 (CASP1) Antibody
20-abx100445
  • EUR 439.00
  • EUR 133.00
  • EUR 1247.00
  • EUR 592.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Caspase 1 (CASP1) Antibody
20-abx100446
  • EUR 467.00
  • EUR 133.00
  • EUR 1358.00
  • EUR 648.00
  • EUR 356.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Caspase 1 (CASP1) Antibody
abx037580-100ug 100 ug
EUR 391

Caspase 1 (CASP1) Antibody
abx038263-100ug 100 ug
EUR 391

Caspase 1 (CASP1) Antibody
20-abx007565
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Caspase 1 p20 Antibody
20-abx009515
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Caspase 1 (CASP1) Antibody
20-abx009516
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Caspase 1 (CASP1) Antibody
20-abx009517
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Caspase 1 (CASP1) Antibody
20-abx000918
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Caspase-1 Polyclonal Antibody
ABP50851-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of Caspase-1 from Human, Mouse, Rat. This Caspase-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Caspase-1 around the non-phosphorylation site of S376

Caspase-1 Polyclonal Antibody
ABP50851-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of Caspase-1 from Human, Mouse, Rat. This Caspase-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Caspase-1 around the non-phosphorylation site of S376

Caspase-1 Polyclonal Antibody
ABP50851-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of Caspase-1 from Human, Mouse, Rat. This Caspase-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Caspase-1 around the non-phosphorylation site of S376

Caspase-1 Polyclonal Antibody
ABP56678-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of Caspase-1 from Human, Monkey. This Caspase-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Caspase-1 at AA range: 270-350

Caspase-1 Polyclonal Antibody
ABP56678-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of Caspase-1 from Human, Monkey. This Caspase-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Caspase-1 at AA range: 270-350

Caspase-1 Polyclonal Antibody
ABP56678-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of Caspase-1 from Human, Monkey. This Caspase-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human Caspase-1 at AA range: 270-350

A brand new program, TALOS-N, is launched for predicting protein spine torsion angles from NMR chemical shifts. The program depends much more extensively on the usage of educated synthetic neural networks than its predecessor, TALOS+. Validation on an impartial set of proteins indicates that spine torsion angles can be predicted for a bigger, ≥90 % fraction of the residues, with an error price smaller than ca 3.5 %, utilizing an acceptance criterion that’s practically two-fold tighter than that used beforehand, and a root imply sq. distinction between predicted and crystallographically noticed (ϕ, ψ) torsion angles of ca 12º. TALOS-N additionally reviews sidechain χ(1) rotameric states for about 50 % of the residues, and a consistency with reference constructions of 89 %.

Interaction of tRNA with 23S rRNA in the ribosomal A, P, and E sites.

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Interaction of tRNA with 23S rRNA in the ribosomal A, P, and E sites.

Three units of conserved nucleotides in 23 rRNA are shielded from chemical probes by binding of tRNA to the ribosomal A, P, and E websites, respectively. They are situated nearly solely in area V, primarily in or adjoining to the loop recognized with the peptidyl transferase operate. Some of these websites are additionally protected by antibiotics equivalent to chloramphenicol, which might clarify how these medicine intervene with protein synthesis. Certain tRNA-dependent protections are abolished when the 3′-terminal A or CA or 2′,3′-linked acyl group is eliminated, offering direct proof for the interplay of the conserved CCA terminus of tRNA with 23S rRNA.

When the EF-Tu.GTP.aminoacyl-tRNA ternary advanced is sure to the ribosome, no tRNA-dependent A web site protections are detected in 23S rRNA till EF-Tu is launched. Thus, EF-Tu prevents interplay of the 3′ terminus of the incoming aminoacyl-tRNA with the peptidyl transferase area of the ribosome throughout anticodon choice, thereby allowing translational proofreading. Some PLTS cells appeared to have two axonal origins from the somata and dendrites. LA cells had been principally massive aspiny cells with Ca(2+)-dependent long-lasting afterhyperpolarizations and robust time-dependent hyperpolarizing rectification.

Plants have advanced subtle programs to manage with herbivore challenges. When vegetation understand herbivore-derived bodily and chemical cues, equivalent to elicitors in bugs’ oral secretions and compounds in oviposition fluids, vegetation dramatically reshape their transcriptomes, proteomes, and metabolomes. All these herbivory-induced modifications are mediated by elaborate signaling networks, which embrace receptors/sensors, Ca(2+) influxes, kinase cascades, reactive oxygen species, and phytohormone signaling pathways. Furthermore, herbivory induces protection responses not solely in the wounded areas but additionally in undamaged areas in the attacked leaves and in distal intact (systemic) leaves.

Here, we overview current progress in understanding plant notion of herbivory and oviposition, and the herbivory-induced early signaling occasions and their organic features. We think about the intraspecific phenotypic variety of plant responses to herbivory and focus on the underlying genetic variation. We additionally focus on new instruments and technical challenges in learning plant-herbivore interactions. Our outcomes point out that TRPA1 is an oxidant sensor in sensory neurons, initiating neuronal excitation and subsequent physiological responses in vitro and in vivo.

The impact of cyanide on the efflux of calcium from squid axons.

The common charge fixed for loss of (45)Ca from an unpoisoned squid axon was 1.Eight x 10(-3) min(-1), similar to an efflux of 0.2 p-mole/cm(2) sec.2. The Ca efflux from unpoisoned axons was diminished if exterior calcium was changed with magnesium, or exterior sodium with lithium, choline or dextrose. Replacing each sodium and calcium diminished the efflux to about 40%.3. Cyanide triggered little quick change in Ca efflux however after 1(half of)-2(half of) hr the efflux elevated to 5-15 instances its regular worth. The impact was quickly reversed when cyanide was eliminated.4.

The giant Ca efflux into cyanide was diminished by an element of three when exterior calcium was changed with magnesium and by an extra issue of about six when exterior sodium was changed with lithium.5. The Ca efflux from each poisoned and unpoisoned axons had a Q(10) of 2-3, was not affected by ouabain and was vastly diminished by injecting ethyleneglycol bis (aminoethylether)-N,N’-tetra-acetic acid (EGTA).6. After injecting (45)Ca alongside the axis, the efflux of calcium reached its most rather more quickly in a cyanide-treated axon than in an unpoisoned axon.7. Pre-treatment with cyanide vastly elevated the charge at which calcium was misplaced from axoplasm extruded into flattened dialysis luggage.

The same impact was noticed when cyanide was utilized after extrusion.8. Replacing exterior sodium glutamate with potassium glutamate vastly diminished the loss of (45)Ca from intact axons poisoned with cyanide however had little impact on the loss from extruded axoplasm.9. The charge fixed for loss of the Ca EGTA advanced was about Three x 10(-5) min(-1) for intact axons and 2 x 10(-2) min(-1) for extruded axoplasm.10. A doable clarification of the cyanide impact is that, after poisoning, calcium ions are launched from a retailer and can then change at a better charge with exterior sodium or calcium.11. The experiments counsel that half of the calcium efflux could also be coupled to sodium entry.12. Theoretical equations for ;diffusion and chemical response in a cylinder’ are described in the Appendix.

Interaction of tRNA with 23S rRNA in the ribosomal A, P, and E sites.

TRPA1 is a serious oxidant sensor in murine airway sensory neurons.

Sensory neurons in the airways are finely tuned to answer reactive chemical substances threatening airway operate and integrity. Nasal trigeminal nerve endings are significantly delicate to oxidants shaped in polluted air and throughout oxidative stress in addition to to chlorine, which is steadily launched in industrial and home accidents. Oxidant activation of airway neurons induces respiratory melancholy, nasal obstruction, sneezing, cough, and ache. While usually protecting, chemosensory airway reflexes can provoke extreme issues in sufferers affected by inflammatory airway circumstances like rhinitis and bronchial asthma.

Caspase-9 Antibody
24050-100ul 100ul
EUR 390

Caspase-9 Antibody
48161-100ul 100ul
EUR 333

Caspase-9 Antibody
48161-50ul 50ul
EUR 239

Caspase-9 Antibody
48687-100ul 100ul
EUR 333

Caspase-9 Antibody
48687-50ul 50ul
EUR 239

Caspase-9 Antibody
49014-100ul 100ul
EUR 333

Caspase-9 Antibody
49014-50ul 50ul
EUR 239

Caspase 9 Antibody
AF6348 200ul
EUR 304
Description: Caspase 9 Antibody detects endogenous levels of total Caspase 9.

Caspase 9 Antibody
ABF6348 100 ug
EUR 438

Caspase-9 Antibody
6670-100
EUR 338

Caspase-9 Antibody
6670-30T
EUR 146

Caspase-9 Antibody
3016-100
EUR 338

Caspase-9 Antibody
3016-30T
EUR 146

Caspase-9 Antibody
3136-100
EUR 327

Caspase-9 Antibody
3136-30T
EUR 146

Caspase-9 Antibody
3409-100
EUR 316

Caspase-9 Antibody
3409-30T
EUR 146

Caspase 9 antibody
20R-2497 50 ug
EUR 281
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody
20R-1425 100 ug
EUR 673
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody
20R-1468 100 ug
EUR 673
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody
20R-1472 100 ug
EUR 781
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody
20R-1557 100 ug
EUR 673
Description: Rabbit polyclonal Caspase 9 antibody

Caspase-9 Antibody
2071-002mg 0.02 mg
EUR 171.82
Description: Caspase-9 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3. Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation. Caspase-9 is also activated by granzyme B and CPP32. Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFα, TRAIL, anti-CD-95, FADD, and TRADD. Caspase-9 is expressed in a variety of human tissues.

Caspase-9 Antibody
2071-01mg 0.1 mg
EUR 436.42
Description: Caspase-9 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3. Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation. Caspase-9 is also activated by granzyme B and CPP32. Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFα, TRAIL, anti-CD-95, FADD, and TRADD. Caspase-9 is expressed in a variety of human tissues.

Caspase-9 Antibody
2073-002mg 0.02 mg
EUR 171.82
Description: Caspase-9 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3. Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation. Caspase-9 is also activated by granzyme B and CPP32. Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFα, TRAIL, anti-CD-95, FADD, and TRADD. Caspase-9 is expressed in a variety of human tissues.

Caspase-9 Antibody
2073-01mg 0.1 mg
EUR 436.42
Description: Caspase-9 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3. Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation. Caspase-9 is also activated by granzyme B and CPP32. Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFα, TRAIL, anti-CD-95, FADD, and TRADD. Caspase-9 is expressed in a variety of human tissues.

Caspase 9 antibody
70R-30659 100 ug
EUR 327
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody
70R-31082 100 ug
EUR 327
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody
70R-31083 100 ug
EUR 327
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody
70R-31084 100 ug
EUR 327
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody
70R-33457 100 ug
EUR 327
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody
70R-33459 100 ug
EUR 327
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody
70R-33461 100 ug
EUR 327
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody
70R-11636 100 ug
EUR 418
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody
70R-11806 100 ug
EUR 403
Description: Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody
70R-13511 100 ul
EUR 457
Description: Affinity purified Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody
70R-14132 100 ug
EUR 322
Description: Affinity purified Rabbit polyclonal Caspase 9 antibody

Caspase 9 antibody
70R-51476 100 ul
EUR 244
Description: Purified Polyclonal Caspase 9 antibody

Caspase 9 antibody
70R-49474 100 ul
EUR 244
Description: Purified Polyclonal Caspase 9 antibody

Caspase 9 antibody
70R-49475 100 ul
EUR 244
Description: Purified Polyclonal Caspase 9 antibody

Caspase-9
GT15045 100 ul
EUR 500

Caspase-9 Polyclonal Antibody
ES7743-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Caspase-9 from Human/Monkey. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Caspase-9 Polyclonal Antibody
ES7743-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Caspase-9 from Human/Monkey. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Caspase 9 Monoclonal Antibody
EM1077-100ul 100ul
EUR 279
Description: A Mouse Monoclonal antibody against Caspase 9 from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IP, IF

Caspase 9 Monoclonal Antibody
EM1077-50ul 50ul
EUR 207
Description: A Mouse Monoclonal antibody against Caspase 9 from Human/ Rat/ Mouse. This antibody is tested and validated for WB, ELISA, IP, IF

Caspase-9 Polyclonal Antibody
ES1860-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Caspase-9 from Human. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Caspase-9 Polyclonal Antibody
ES1858-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Caspase-9 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Caspase-9 Polyclonal Antibody
ES1858-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Caspase-9 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Caspase-9 Polyclonal Antibody
ES1859-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Caspase-9 from Human/Monkey. This antibody is tested and validated for WB, ELISA, WB, ELISA

Caspase-9 Polyclonal Antibody
ES1859-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Caspase-9 from Human/Monkey. This antibody is tested and validated for WB, ELISA, WB, ELISA

Caspase-9 Polyclonal Antibody
ES1860-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Caspase-9 from Human. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Polyclonal Caspase-9 Antibody
APG02416G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-9 . This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-9 Antibody
APG02417G 0.1 mg
EUR 659
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Caspase-9 . This antibody is tested and proven to work in the following applications:

Polyclonal Caspase-9 Antibody
APG02418G 0.1 mg