Chemical shift perturbation (CSP, chemical shift mapping or complexation-induced modifications in chemical shift, CIS) follows modifications within the chemical shifts of a protein when a ligand is added, and makes use of these to decide the placement of the binding web site, the affinity of the ligand, and/or presumably the construction of the advanced. A key consider figuring out the looks of spectra throughout a titration is the change price between free and certain, or extra particularly the off-rate koff. When koff is bigger than the chemical shift distinction between free and certain, which generally equates to an affinity Kd weaker than about 3μM, then change is quick on the chemical shift timescale.
Under these circumstances, the noticed shift is the population-weighted common of free and certain, which permits Kd to be decided from measurement of peak positions, offered the measurements are made appropriately. (1)H shifts are influenced to a big extent by through-space interactions, whereas (13)Cα and (13)Cβ shifts are influenced extra by through-bond results. (15)N and (13)C’ shifts are influenced each by through-bond and by through-space (hydrogen bonding) interactions. For figuring out the placement of a certain ligand on the idea of shift change, probably the most acceptable methodology is subsequently normally to measure (15)N HSQC spectra, calculate the geometrical distance moved by the height, weighting (15)N shifts by an element of about 0.14 in contrast to (1)H shifts, and choose these residues for which the weighted shift change is bigger than the usual deviation of the shift for all residues.
Other strategies are mentioned, particularly the measurement of (13)CH3 indicators. Slow to intermediate change charges lead to line broadening, and make Kd values very troublesome to acquire. There isn’t any great way to distinguish modifications in chemical shift due to direct binding of the ligand from modifications in chemical shift due to allosteric change. Ligand binding at a number of websites can typically be characterised, by simultaneous becoming of many measured shift modifications, or extra just by including substoichiometric quantities of ligand. The chemical shift modifications can be utilized as restraints for docking ligand onto protein. By use of quantitative calculations of ligand-induced chemical shift modifications, it’s changing into potential to decide not simply the place but in addition the orientation of ligands.
Glutamate and neurotrophic elements in neuronal plasticity and illness.
Glutamate’s position as a neurotransmitter at synapses has been recognized for 40 years, however glutamate has since been proven to regulate neurogenesis, neurite outgrowth, synaptogenesis, and neuron survival within the creating and grownup mammalian nervous system. Cell-surface glutamate receptors are coupled to Ca(2+) inflow and launch from endoplasmic reticulum shops, which causes speedy (kinase- and protease-mediated) and delayed (transcription-dependent) responses that change the construction and performance of neurons. Neurotrophic elements and glutamate work together to regulate developmental and grownup neuroplasticity. For instance, glutamate stimulates the manufacturing of brain-derived neurotrophic issue (BDNF), which, in flip, modifies neuronal glutamate sensitivity, Ca(2+) homeostasis, and plasticity.
Neurotrophic elements could modify glutamate signaling straight, by altering the expression of glutamate receptor subunits and Ca(2+)-regulating proteins, and likewise not directly by inducing the manufacturing of antioxidant enzymes, energy-regulating proteins, and antiapoptotic Bcl-2 relations. Excessive activation of glutamate receptors, beneath situations of oxidative and metabolic stress, could contribute to neuronal dysfunction and degeneration in ailments starting from stroke and Alzheimer’s illness to psychiatric issues. By enhancing neurotrophic issue signaling, environmental elements comparable to train and dietary vitality restriction, and chemical compounds comparable to antidepressants could optimize glutamatergic signaling and shield in opposition to neurological issues.
Glial cells in (patho)physiology.
Neuroglial cells outline mind homeostasis and mount protection in opposition to pathological insults. Astroglia regulate neurogenesis and improvement of mind circuits. In the grownup mind, astrocytes enter into intimate dynamic relationship with neurons, particularly at synaptic websites the place they functionally kind the tripartite synapse. At these websites, astrocytes regulate ion and neurotransmitter homeostasis, metabolically help neurons and monitor synaptic exercise; one of many readouts of the latter manifests in astrocytic intracellular Ca(2+) indicators. This type of astrocytic excitability can lead to launch of chemical transmitters by way of Ca(2+) -dependent exocytosis.
Once within the extracellular area, gliotransmitters can modulate synaptic plasticity and trigger modifications in habits. Besides these physiological duties, astrocytes are elementary for development and final result of neurological ailments. In Alzheimer’s illness, for instance, astrocytes could contribute to the etiology of this dysfunction. Highly deadly glial-derived tumors use signaling trickery to coerce regular mind cells to help tumor invasiveness. This evaluation not solely sheds new gentle on the mind operation in well being and illness, but in addition factors to many unknowns.
Caspase 5 p10 Antibody |
20-abx009504 |
Abbexa |
-
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|
Caspase 5 p10 Antibody |
E38PA1145 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Caspase 5 p10 antibody |
70R-49464 |
Fitzgerald |
100 ul |
EUR 242 |
|
Description: Purified Polyclonal Caspase 5 p10 antibody |
Caspase 14 p10 antibody |
70R-50903 |
Fitzgerald |
100 ul |
EUR 242 |
|
Description: Purified Polyclonal Caspase 14 p10 antibody |
Caspase 1 (p10, Cleaved-Ala317) Antibody |
20-abx015550 |
Abbexa |
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- 100 ug
- 10 ug
- 200 ug
- 300 µg
|
|
Caspase 1 (p10, Cleaved-Ala317) Antibody |
E11-0141L |
EnoGene |
100μg/100μl |
EUR 225 |
Description: Available in various conjugation types. |
Polyclonal Anti- Caspase-3 (P10) Antibody |
GWB-BBP182 |
GenWay Biotech |
0.1 mg |
Ask for price |
OABB00476-100UG - Caspase-1 (p10) Polyclonal Antibody |
OABB00476-100UG |
Aviva Systems Biology |
100ug |
EUR 419 |
|
Caspase 14 (p10, Cleaved-Lys222) Antibody |
20-abx015552 |
Abbexa |
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- 100 ug
- 10 ug
- 200 ug
- 300 µg
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|
Caspase 5 (p10, Cleaved-Ser331) Antibody |
20-abx015560 |
Abbexa |
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- 100 ug
- 10 ug
- 200 ug
- 300 µg
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Caspase 14 (p10, Cleaved-Lys222) Antibody |
E11-0148L |
EnoGene |
100μg/100μl |
EUR 225 |
Description: Available in various conjugation types. |
Caspase-3(P10) |
PA1302 |
Antagene |
100μg |
EUR 260 |
Caspase-3 (P10) |
PA1302-M |
Antagene |
100μg |
EUR 290 |
Description: Polyclonal Antibodies Conjugated to Magnetic Beads |
Caspase-3 (P10) |
PA1302-S |
Antagene |
100μg |
EUR 290 |
Description: Polyclonal Antibodies Conjugated to Sepharose Beads |
OABB00478-100UG - Caspase-8 (P10) Polyclonal Antibody |
OABB00478-100UG |
Aviva Systems Biology |
100ug |
EUR 419 |
|
Caspase 1 p10 Blocking Peptide |
20-abx062325 |
Abbexa |
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Caspase 5 Subunit p10 Cleaved-Ser331 (CASP5 p10 Cleaved-S331) Antibody |
abx015560-1mg |
Abbexa |
1 mg |
EUR 43.75 |
Caspase 14 Subunit p10 Cleaved-Lys222 (CASP14 p10 Cleaved-Ks222) Antibody |
abx015552-1mg |
Abbexa |
1 mg |
EUR 43.75 |
Caspase 5 p10 Blocking Peptide |
20-abx062339 |
Abbexa |
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Caspase 14 p10 Blocking Peptide |
20-abx063778 |
Abbexa |
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Rat Caspase-1 subunit p10 ELISA Kit |
E01A12807 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Goat Caspase-1 subunit p10 ELISA Kit |
E01A47717 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Mouse Caspase-1 subunit p10 ELISA Kit |
E01A21548 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Human Caspase-1 subunit p10 ELISA Kit |
E01A4044 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Sheep Caspase-1 subunit p10 ELISA Kit |
E01A100011 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Caspase 1 Subunit 10 Cleaved-Ala317 (CASP1 p10 Cleaved-A317) Antibody |
abx015550-1mg |
Abbexa |
1 mg |
EUR 43.75 |
Canine Caspase-1 subunit p10 ELISA Kit |
E01A65149 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Monkey Caspase-1 subunit p10 ELISA Kit |
E01A73863 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Rabbit Caspase-1 subunit p10 ELISA Kit |
E01A30285 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Bovine Caspase-1 subunit p10 ELISA Kit |
E01A82582 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Caspase-1 subunit p10 ELISA Kit |
E01A56434 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Chicken Caspase-1 subunit p10 ELISA Kit |
E01A91304 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Cleaved Caspase-1 (Arg317) /P10 Blocking Peptide |
AF4022-BP |
Affbiotech |
1mg |
EUR 234 |
Caspase 1 p20 Antibody |
20-abx009515 |
Abbexa |
-
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|
Caspase 1 p20 antibody |
70R-49453 |
Fitzgerald |
100 ul |
EUR 242 |
|
Description: Purified Polyclonal Caspase 1 p20 antibody |
Guinea Pig Caspase-1 subunit p10 ELISA Kit |
E01A38999 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Rat Caspase-8 subunit p10 ELISA kit |
E01A12785 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Rat Caspase-9 subunit p10 ELISA kit |
E01A12787 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Goat Caspase-8 subunit p10 ELISA kit |
E01A47696 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Goat Caspase-9 subunit p10 ELISA kit |
E01A47698 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Caspase-1 Antibody (p20) |
R30510 |
NSJ Bioreagents |
100 ug |
EUR 356.15 |
|
Description: Caspase-1 is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta, interleukin 18, and interleukin 33 precursor proteins. The Caspase-1 gene consists of 10 exons spanning at least 10.6 kb and is mapped to 11q23, a site frequently involved in rearrangement in human cancers, including a number of leukemias and lymphomas. |
Caspase-1 Antibody (p20) |
R30511 |
NSJ Bioreagents |
100 ug |
EUR 356.15 |
|
Description: Caspase-1 is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta, IL-18, and IL-33 precursor proteins. It belongs to a family of cysteine proteases known as caspases that always cleave proteins following an aspartic acid residue. The Caspase-1 gene consists of 10 exons spanning at least 10.6 kb and is mapped to 11q23, a site frequently involved in rearrangement in human cancers, including a number of leukemias and lymphomas, by Southern DNA blot analysis of rodent-human hybrids and by in situ hybridization to normal human metaphase chromosomes. Caspase 1 has been shown to induce cell necrosis or pyroptosis and may function in various developmental stages. |
Caspase 4 (p10, Cleaved-Ala290) rabbit pAb |
E28PC0119 |
EnoGene |
100μl |
EUR 255 |
Description: Available in various conjugation types. |
Caspase 4 (p10, Cleaved-Ala290) rabbit pAb |
E44H11401 |
EnoGene |
100ul |
EUR 255 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
Mouse Caspase-8 subunit p10 ELISA kit |
E01A21526 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Mouse Caspase-9 subunit p10 ELISA kit |
E01A21528 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Human Caspase-8 subunit p10 ELISA kit |
E01A4023 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Human Caspase-9 subunit p10 ELISA kit |
E01A4025 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Sheep Caspase-8 subunit p10 ELISA kit |
E01A99990 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Sheep Caspase-9 subunit p10 ELISA kit |
E01A99992 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Canine Caspase-8 subunit p10 ELISA kit |
E01A65128 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Canine Caspase-9 subunit p10 ELISA kit |
E01A65130 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Monkey Caspase-8 subunit p10 ELISA kit |
E01A73842 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Monkey Caspase-9 subunit p10 ELISA kit |
E01A73844 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Rabbit Caspase-8 subunit p10 ELISA kit |
E01A30263 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Rabbit Caspase-9 subunit p10 ELISA kit |
E01A30265 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Bovine Caspase-8 subunit p10 ELISA kit |
E01A82561 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Bovine Caspase-9 subunit p10 ELISA kit |
E01A82563 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Caspase-8 subunit p10 ELISA kit |
E01A56413 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Porcine Caspase-9 subunit p10 ELISA kit |
E01A56415 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Chicken Caspase-8 subunit p10 ELISA kit |
E01A91283 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Chicken Caspase-9 subunit p10 ELISA kit |
E01A91285 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Hamster Caspase-8 subunit p10 ELISA kit |
E01A104825 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Hamster Caspase-9 subunit p10 ELISA kit |
E01A104827 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Caspase-1 Antibody |
24290-100ul |
SAB |
100ul |
EUR 468 |
Caspase-1 Antibody |
24291-100ul |
SAB |
100ul |
EUR 468 |
Caspase-1 Antibody |
3019-100 |
Biovision |
each |
EUR 483.6 |
Caspase-1 Antibody |
3019-30T |
Biovision |
each |
EUR 175.2 |
Caspase-1 Antibody |
48847-100ul |
SAB |
100ul |
EUR 399.6 |
Caspase-1 Antibody |
48847-50ul |
SAB |
50ul |
EUR 286.8 |
Caspase-1 Antibody |
3459-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
Description: Caspase-1 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1β and IL-18. Caspase-1 was initially identified as an IL-1β-converting enzyme; later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 whose overexpression can induce apoptosis in fibroblasts. |
Caspase-1 Antibody |
3459-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
|
Description: Caspase-1 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1β and IL-18. Caspase-1 was initially identified as an IL-1β-converting enzyme; later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 whose overexpression can induce apoptosis in fibroblasts. |
Caspase-1 Antibody |
3463-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
Description: Caspase-1 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1β and IL-18. Caspase-1 was initially identified as an IL-1β-converting enzyme; later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 whose overexpression can induce apoptosis in fibroblasts. |
Caspase-1 Antibody |
3463-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
|
Description: Caspase-1 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1β and IL-18. Caspase-1 was initially identified as an IL-1β-converting enzyme; later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 whose overexpression can induce apoptosis in fibroblasts. |
Guinea Pig Caspase-8 subunit p10 ELISA kit |
E01A38978 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Guinea Pig Caspase-9 subunit p10 ELISA kit |
E01A38980 |
BlueGene |
96T |
EUR 700 |
Description: ELISA |
Caspase 9 p35 Antibody |
20-abx121860 |
Abbexa |
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Caspase 3 p12 Antibody |
20-abx141269 |
Abbexa |
-
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Caspase 9 p35 Antibody |
20-abx141270 |
Abbexa |
-
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Caspase 8 p18 Antibody |
20-abx133383 |
Abbexa |
-
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Caspase 4 p20 Antibody |
20-abx007564 |
Abbexa |
-
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Caspase 7 p11 Antibody |
20-abx009499 |
Abbexa |
-
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Caspase 6 p18 Antibody |
20-abx009501 |
Abbexa |
-
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|
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Caspase 6 p18 Antibody |
20-abx009502 |
Abbexa |
-
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Caspase 5 p20 Antibody |
20-abx009503 |
Abbexa |
-
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|
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Caspase 4 p20 Antibody |
20-abx009505 |
Abbexa |
-
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|
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Caspase 3 p17 Antibody |
20-abx009507 |
Abbexa |
-
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|
|
Caspase 3 p17 Antibody |
20-abx009508 |
Abbexa |
-
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Caspase 3 p17 Antibody |
20-abx009509 |
Abbexa |
-
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Caspase 2 p18 Antibody |
20-abx009513 |
Abbexa |
-
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|
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Caspase 2 p18 Antibody |
20-abx009514 |
Abbexa |
-
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|
|
Caspase 7 p20 Antibody |
E38PA6277 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Caspase 8 p18 Antibody |
E38PA6278 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Caspase 2 p18 Antibody |
E38PA1136 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Caspase 3 p17 Antibody |
E38PA1141 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Caspase 3 p17 Antibody |
E38PA1142 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Caspase 5 p20 Antibody |
E38PA1146 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Caspase 6 p18 Antibody |
E38PA1147 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Caspase 6 p18 Antibody |
E38PA1148 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Caspase 2 p18 antibody |
70R-49454 |
Fitzgerald |
100 ul |
EUR 242 |
|
Description: Purified Polyclonal Caspase 2 p18 antibody |
Caspase 2 p18 antibody |
70R-49455 |
Fitzgerald |
100 ul |
EUR 242 |
|
Description: Purified Polyclonal Caspase 2 p18 antibody |
Caspase 3 p17 antibody |
70R-49459 |
Fitzgerald |
100 ul |
EUR 242 |
|
Description: Purified Polyclonal Caspase 3 p17 antibody |
Caspase 3 p17 antibody |
70R-49460 |
Fitzgerald |
100 ul |
EUR 242 |
|
Description: Purified Polyclonal Caspase 3 p17 antibody |
Caspase 3 p17 antibody |
70R-49461 |
Fitzgerald |
100 ul |
EUR 242 |
|
Description: Purified Polyclonal Caspase 3 p17 antibody |
Caspase 4 p20 antibody |
70R-49463 |
Fitzgerald |
100 ul |
EUR 242 |
|
Description: Purified Polyclonal Caspase 4 p20 antibody |
Caspase 5 p20 antibody |
70R-49465 |
Fitzgerald |
100 ul |
EUR 242 |
|
Description: Purified Polyclonal Caspase 5 p20 antibody |
Caspase 6 p18 antibody |
70R-49466 |
Fitzgerald |
100 ul |
EUR 242 |
|
Description: Purified Polyclonal Caspase 6 p18 antibody |
Caspase 6 p18 antibody |
70R-49467 |
Fitzgerald |
100 ul |
EUR 242 |
|
Description: Purified Polyclonal Caspase 6 p18 antibody |
Caspase 7 p11 antibody |
70R-49469 |
Fitzgerald |
100 ul |
EUR 242 |
|
Description: Purified Polyclonal Caspase 7 p11 antibody |
Caspase 4 p20 antibody |
70R-51475 |
Fitzgerald |
100 ul |
EUR 242 |
|
Description: Purified Polyclonal Caspase 4 p20 antibody |
Caspase-6 p18 Antibody |
49099 |
SAB |
100ul |
EUR 499 |
Caspase-6 p18 Antibody |
49099-100ul |
SAB |
100ul |
EUR 399.6 |
Caspase-6 p18 Antibody |
49099-50ul |
SAB |
50ul |
EUR 286.8 |
Caspase 1 Antibody |
6687-100 |
Biovision |
each |
EUR 405.6 |
Caspase 1 Antibody |
6687-30T |
Biovision |
each |
EUR 175.2 |
Caspase 1 antibody |
20R-1427 |
Fitzgerald |
100 ug |
EUR 781.2 |
Description: Rabbit polyclonal Caspase 1 antibody |
caspase 1 Antibody |
39310-100ul |
SAB |
100ul |
EUR 468 |
Caspase 1 Antibody |
E18-5418-1 |
EnoGene |
50μg/50μl |
EUR 145 |
Description: Available in various conjugation types. |
Caspase 1 Antibody |
E18-5418-2 |
EnoGene |
100μg/100μl |
EUR 225 |
Description: Available in various conjugation types. |
Caspase 1 Antibody |
DF6148 |
Affbiotech |
200ul |
EUR 420 |
Caspase 1 Antibody |
E38PA5426 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
Caspase 1 Antibody |
E38PA1133 |
EnoGene |
100ul |
EUR 225 |
Description: Available in various conjugation types. |
caspase 1 Antibody |
E300022a |
EnoGene |
100ug/200ul |
EUR 275 |
Description: Available in various conjugation types. |
caspase 1 Antibody |
E300022b |
EnoGene |
200ul |
EUR 275 |
Description: Available in various conjugation types. |
Caspase 1 antibody |
70R-13979 |
Fitzgerald |
100 ug |
EUR 519 |
|
Description: Affinity purified Rabbit polyclonal Caspase 1 antibody |
Caspase 1 antibody |
70R-14061 |
Fitzgerald |
100 ug |
EUR 519 |
|
Description: Affinity purified Rabbit polyclonal Caspase 1 antibody |
Caspase 1 antibody |
70R-15367 |
Fitzgerald |
100 ug |
EUR 302 |
|
Description: Rabbit polyclonal Caspase 1 antibody |
Caspase 1 antibody |
70R-11561 |
Fitzgerald |
100 ug |
EUR 490 |
|
Description: Rabbit polyclonal Caspase 1 antibody |
Caspase 1 antibody |
70R-31086 |
Fitzgerald |
100 ug |
EUR 294 |
|
Description: Rabbit polyclonal Caspase 1 antibody |
Caspase 1 antibody |
70R-31087 |
Fitzgerald |
100 ug |
EUR 294 |
|
Description: Rabbit polyclonal Caspase 1 antibody |
Caspase 1 antibody |
70R-31116 |
Fitzgerald |
100 ug |
EUR 294 |
|
Description: Rabbit polyclonal Caspase 1 antibody |
Caspase 1 antibody |
70R-35920 |
Fitzgerald |
100 ug |
EUR 294 |
|
Description: Rabbit polyclonal Caspase 1 antibody |
Caspase 1 antibody |
70R-49451 |
Fitzgerald |
100 ul |
EUR 242 |
|
Description: Purified Polyclonal Caspase 1 antibody |
Caspase 1 antibody |
70R-49452 |
Fitzgerald |
100 ul |
EUR 242 |
|
Description: Purified Polyclonal Caspase 1 antibody |
A brand new program, TALOS-N, is launched for predicting protein spine torsion angles from NMR chemical shifts. The program depends much more extensively on the usage of educated synthetic neural networks than its predecessor, TALOS+. Validation on an impartial set of proteins indicates that spine torsion angles can be predicted for a bigger, ≥90 % fraction of the residues, with an error price smaller than ca 3.5 %, utilizing an acceptance criterion that’s practically two-fold tighter than that used beforehand, and a root imply sq. distinction between predicted and crystallographically noticed (ϕ, ψ) torsion angles of ca 12º. TALOS-N additionally reviews sidechain χ(1) rotameric states for about 50 % of the residues, and a consistency with reference constructions of 89 %.