Primary construction of the Aequorea victoria green-fluorescent protein.
Many cnidarians make the most of green-fluorescent proteins (GFPs) as energy-transfer acceptors in bioluminescence. GFPs fluoresce in vivo upon receiving vitality from both a luciferase-oxyluciferin excited-state advanced or a Ca(2+)-activated phosphoprotein. These extremely fluorescent proteins are distinctive because of the chemical nature of their chromophore, which is comprised of modified amino acid (aa) residues throughout the polypeptide. This report describes the cloning and sequencing of each cDNA and genomic clones of GFP from the cnidarian, Aequorea victoria.
The gfp10 cDNA encodes a 238-aa-residue polypeptide with a calculated Mr of 26,888. Comparison of A. victoria GFP genomic clones reveals three totally different restriction enzyme patterns which means that at the least three totally different genes are current within the A. victoria inhabitants at Friday Harbor, Washington. The gfp gene encoded by the lambda GFP2 genomic clone is comprised of at the least three exons unfold over 2.6 kb. The nucleotide sequences of the cDNA and the gene will help within the elucidation of structure-function relationships on this distinctive class of proteins.
Citations in CAS SciFinder to the rule-of-five (RO5) publication will exceed 1000 by year-end 2004. Trends within the RO5 literature explosion that may be discerned are the additional definitions of drug-like. This matter is explored when it comes to drug-like physicochemical options, drug-like structural options, a comparability of drug-like and non-drug-like in drug discovery and a dialogue of how drug-like options relate to medical success. Physicochemical options of CNS medicine and options associated to CNS blood-brain transporter affinity are briefly reviewed. Recent literature on options of non-oral medicine is reviewed and the way options of lead-like compounds differ from these of drug-like compounds is mentioned.

In vitro molecular mechanisms of bisphenol A motion.
Bisphenol A (BPA, 2,2-bis (4-hydroxyphenyl) propane; CAS# 80-05-7) is a chemical used primarily within the manufacture of polycarbonate plastic, epoxy resins and as a non-polymer additive to different plastics. Recent proof has demonstrated that human and wildlife populations are uncovered to ranges of BPA which trigger adversarial reproductive and developmental results in various totally different wildlife species and laboratory animal fashions. However, there are main uncertainties surrounding the spectrum of BPA’s mechanisms of motion, the tissue-specific impacts of exposures, and the essential home windows of susceptibility throughout which goal tissues are delicate to BPA exposures.
As a basis to handle a few of these uncertainties, this evaluation was ready by the “In vitro” professional sub-panel assembled in the course of the “Bisphenol A: An Examination of the Relevance of Ecological, In vitro and Laboratory Animal Studies for Assessing Risks to Human Health” workshop held in Chapel Hill, NC, Nov 28-29, 2006. The particular cost of this professional panel was to evaluation and assess the energy of the revealed literature pertaining to the mechanisms of BPA motion. The ensuing doc is an in depth evaluation of revealed research which have centered on the mechanistic foundation of BPA motion in various experimental fashions and an evaluation of the energy of the proof relating to the revealed BPA analysis.
In its present state, the database employs an easy-to-use, searchable interface for acquiring detailed information on the 109 at present recognized RNA modifications. Each entry gives the chemical construction, frequent identify and image, elemental composition and mass, CA registry numbers and index identify, phylogenetic supply, sort of RNA species wherein it’s discovered, and references to the primary reported construction willpower and synthesis. Though newly transferred in its entirety to The RNA Institute, the RNAMDB continues to develop with two notable additions, agmatidine and 8-methyladenosine, appended within the final 12 months.
CD28 antigen (CD28) polyclonal antibody |
ABP-PAB-10144 |
Allele Biotech |
100 ug |
Ask for price |
|
CD28 Antibody |
1-CSB-PA005199 |
Cusabio |
|
|
|
Description: A polyclonal antibody against CD28. Recognizes CD28 from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000 |
CD28/TP44 |
E21-D81 |
EnoGene |
10ug |
EUR 343 |
CD28 siRNA |
20-abx910984 |
Abbexa |
|
|
|
CD28 siRNA |
20-abx910985 |
Abbexa |
|
|
|
CD28 siRNA |
20-abx900903 |
Abbexa |
|
|
|
CD28 Antibody |
46435-100ul |
SAB |
100ul |
EUR 252 |
CD28 Antibody |
AF0014 |
Affbiotech |
200ul |
EUR 304 |
Description: CD28 antibody detects endogenous levels of CD28. |
anti-CD28 |
YF-PA10780 |
Abfrontier |
50 ug |
EUR 363 |
Description: Mouse polyclonal to CD28 |
CD28 antibody |
10R-6375 |
Fitzgerald |
100 ug |
EUR 192 |
Description: Syrian Hamster monoclonal CD28 antibody |
CD28 antibody |
10R-6376 |
Fitzgerald |
100 ug |
EUR 192 |
Description: Mouse monoclonal CD28 antibody |
CD28 antibody |
10R-CD28bHU |
Fitzgerald |
100 ul |
EUR 467 |
Description: Mouse monoclonal CD28 antibody |
CD28 antibody |
10R-CD28dCKp |
Fitzgerald |
500 ug |
EUR 403 |
Description: Mouse monoclonal CD28 antibody |
CD28 antibody |
10R-CD28dMS |
Fitzgerald |
500 ug |
EUR 370 |
Description: Hamster monoclonal CD28 antibody |
CD28 antibody |
10R-CD28eMS |
Fitzgerald |
500 ug |
EUR 370 |
Description: Hamster monoclonal CD28 antibody |
CD28 Peptide |
42-404P |
ProSci |
0.1 mg |
EUR 338 |
Description: (IN) CD28 Peptide |
Cd28 Peptide |
42-448P |
ProSci |
0.1 mg |
EUR 338 |
Description: (IN) Cd28 Peptide |
CD28 Antibody |
8683-002mg |
ProSci |
0.02 mg |
EUR 171.82 |
|
Description: N/A |
CD28 Antibody |
8683-01mg |
ProSci |
0.1 mg |
EUR 436.42 |
|
Description: N/A |
CD28 Peptide |
8683P |
ProSci |
0.05 mg |
EUR 164.75 |
Description: CD28 peptide |
CD28 antibody |
70R-49503 |
Fitzgerald |
100 ul |
EUR 287 |
Description: Purified Polyclonal CD28 antibody |
CD28 antibody |
70R-9669 |
Fitzgerald |
50 ug |
EUR 467 |
Description: Affinity purified rabbit polyclonal CD28 antibody |
CD28 antibody |
70R-CR045 |
Fitzgerald |
100 ug |
EUR 300 |
Description: Affinity purified Rabbit polyclonal CD28 antibody |
T-cell-specific surface glycoprotein CD28/CD28 |
E21-I67 |
EnoGene |
10ug |
EUR 343 |
Recombinant Cynomolgus CD28 molecule/CD28(C-Fc) |
CB24-10ug |
Novoprotein |
10ug |
EUR 100 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
Recombinant Cynomolgus CD28 molecule/CD28(C-Fc) |
CB24-1mg |
Novoprotein |
1mg |
EUR 1115 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
Recombinant Cynomolgus CD28 molecule/CD28(C-Fc) |
CB24-500ug |
Novoprotein |
500ug |
EUR 780 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
Recombinant Cynomolgus CD28 molecule/CD28(C-Fc) |
CB24-50ug |
Novoprotein |
50ug |
EUR 202 |
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
pCDH-CuO-MCS-T2A-GFP co-inducible T2A lentivector |
QM521A-1 |
SBI |
10 ug |
EUR 679 |
|
pCDH-CuO-MCS-T2A-RFP co-inducible T2A lentivector |
QM522A-1 |
SBI |
10 ug |
EUR 679 |
|
CD28 Polyclonal Antibody |
ES3974-100ul |
ELK Biotech |
100ul |
EUR 279 |
Description: A Rabbit Polyclonal antibody against CD28 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA |
CD28 Polyclonal Antibody |
ES3974-50ul |
ELK Biotech |
50ul |
EUR 207 |
Description: A Rabbit Polyclonal antibody against CD28 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA |
Anti-CD28 antibody |
STJ119563 |
St John's Laboratory |
100 µl |
EUR 277 |
Description: The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
CD28 Polyclonal Antibody |
ABP52975-003ml |
Abbkine |
0.03ml |
EUR 158 |
|
Description: A polyclonal antibody for detection of CD28 from Human. This CD28 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human CD28 |
CD28 Polyclonal Antibody |
ABP52975-01ml |
Abbkine |
0.1ml |
EUR 289 |
|
Description: A polyclonal antibody for detection of CD28 from Human. This CD28 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human CD28 |
CD28 Polyclonal Antibody |
ABP52975-02ml |
Abbkine |
0.2ml |
EUR 414 |
|
Description: A polyclonal antibody for detection of CD28 from Human. This CD28 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human CD28 |
CD28(204.12) Antibody |
BNC040164-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD28(204.12), CF405S conjugate, Concentration: 0.1mg/mL |
CD28(204.12) Antibody |
BNC040164-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD28(204.12), CF405S conjugate, Concentration: 0.1mg/mL |
CD28(CB28) Antibody |
BNC040384-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD28(CB28), CF405S conjugate, Concentration: 0.1mg/mL |
CD28(CB28) Antibody |
BNC040384-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD28(CB28), CF405S conjugate, Concentration: 0.1mg/mL |
CD28(204.12) Antibody |
BNC470164-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD28(204.12), CF647 conjugate, Concentration: 0.1mg/mL |
CD28(204.12) Antibody |
BNC470164-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD28(204.12), CF647 conjugate, Concentration: 0.1mg/mL |
CD28(CB28) Antibody |
BNC470384-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD28(CB28), CF647 conjugate, Concentration: 0.1mg/mL |
CD28(CB28) Antibody |
BNC470384-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD28(CB28), CF647 conjugate, Concentration: 0.1mg/mL |
CD28(204.12) Antibody |
BNC550164-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD28(204.12), CF555 conjugate, Concentration: 0.1mg/mL |
CD28(204.12) Antibody |
BNC550164-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD28(204.12), CF555 conjugate, Concentration: 0.1mg/mL |
CD28(CB28) Antibody |
BNC550384-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD28(CB28), CF555 conjugate, Concentration: 0.1mg/mL |
CD28(CB28) Antibody |
BNC550384-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD28(CB28), CF555 conjugate, Concentration: 0.1mg/mL |
CD28(CB28) Antibody |
BNCAP0384-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD28(CB28), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
CD28(CB28) Antibody |
BNCAP0384-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD28(CB28), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
CD28(204.12) Antibody |
BNCB0164-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD28(204.12), Biotin conjugate, Concentration: 0.1mg/mL |
CD28(204.12) Antibody |
BNCB0164-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD28(204.12), Biotin conjugate, Concentration: 0.1mg/mL |
CD28(CB28) Antibody |
BNCB0384-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD28(CB28), Biotin conjugate, Concentration: 0.1mg/mL |
CD28(CB28) Antibody |
BNCB0384-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD28(CB28), Biotin conjugate, Concentration: 0.1mg/mL |
CD28(204.12) Antibody |
BNC810164-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD28(204.12), CF680R conjugate, Concentration: 0.1mg/mL |
CD28(204.12) Antibody |
BNC810164-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD28(204.12), CF680R conjugate, Concentration: 0.1mg/mL |
CD28(CB28) Antibody |
BNC810384-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD28(CB28), CF680R conjugate, Concentration: 0.1mg/mL |
CD28(CB28) Antibody |
BNC810384-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD28(CB28), CF680R conjugate, Concentration: 0.1mg/mL |
Hamster CD28 Antibody |
abx139999-01mg |
Abbexa |
0.1 mg |
EUR 286 |
|
CD28 (pT218) Antibody |
20-abx009853 |
Abbexa |
-
EUR 314.00
-
EUR 467.00
-
EUR 203.00
|
|
|
CD28(204.12) Antibody |
BNC700164-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD28(204.12), CF770 conjugate, Concentration: 0.1mg/mL |
CD28(204.12) Antibody |
BNC700164-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD28(204.12), CF770 conjugate, Concentration: 0.1mg/mL |
CD28(CB28) Antibody |
BNC700384-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD28(CB28), CF770 conjugate, Concentration: 0.1mg/mL |
CD28(CB28) Antibody |
BNC700384-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD28(CB28), CF770 conjugate, Concentration: 0.1mg/mL |
CD28(204.12) Antibody |
BNC880164-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD28(204.12), CF488A conjugate, Concentration: 0.1mg/mL |
CD28(204.12) Antibody |
BNC880164-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD28(204.12), CF488A conjugate, Concentration: 0.1mg/mL |
CD28(CB28) Antibody |
BNC880384-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD28(CB28), CF488A conjugate, Concentration: 0.1mg/mL |
CD28(CB28) Antibody |
BNC880384-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD28(CB28), CF488A conjugate, Concentration: 0.1mg/mL |
CD28(204.12) Antibody |
BNC940164-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD28(204.12), CF594 conjugate, Concentration: 0.1mg/mL |
CD28(204.12) Antibody |
BNC940164-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD28(204.12), CF594 conjugate, Concentration: 0.1mg/mL |
CD28(CB28) Antibody |
BNC940384-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD28(CB28), CF594 conjugate, Concentration: 0.1mg/mL |
CD28(CB28) Antibody |
BNC940384-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD28(CB28), CF594 conjugate, Concentration: 0.1mg/mL |
CD28(204.12) Antibody |
BNC680164-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD28(204.12), CF568 conjugate, Concentration: 0.1mg/mL |
CD28(204.12) Antibody |
BNC680164-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD28(204.12), CF568 conjugate, Concentration: 0.1mg/mL |
CD28(CB28) Antibody |
BNC680384-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD28(CB28), CF568 conjugate, Concentration: 0.1mg/mL |
CD28(CB28) Antibody |
BNC680384-500 |
Biotium |
500uL |
EUR 544 |
Description: Primary antibody against CD28(CB28), CF568 conjugate, Concentration: 0.1mg/mL |
CD28(204.12) Antibody |
BNCA0164-250 |
Biotium |
250uL |
EUR 383 |
Description: Primary antibody against CD28(204.12), APC conjugate, Concentration: 0.1mg/mL |
CD28(CB28) Antibody |
BNCA0384-250 |
Biotium |
250uL |
EUR 383 |
Description: Primary antibody against CD28(CB28), APC conjugate, Concentration: 0.1mg/mL |
CD28(204.12) Antibody |
BNCAP0164-100 |
Biotium |
100uL |
EUR 199 |
Description: Primary antibody against CD28(204.12), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
The RNA Modification Database is staying up-to-date with important enhancements being ready for inclusion throughout the subsequent 12 months and the next 12 months. The expanded future position of The RNA Modification Database shall be to function a major info portal for researchers throughout the whole spectrum of RNA-related analysis. Most not too long ago, partly pushed by NIH roadmap initiatives, issues have arisen as to what tool-like means within the seek for chemical instruments to probe biology house.